Parasympathetic withdrawal indexes risk for emotion dysregulation in children with autism spectrum disorder.
Parasympathetic withdrawal indexes risk for emotion dysregulation in children with autism spectrum disorder.
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DOI：
10.1002/aur.2814
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发表时间：
2022-11
期刊：
影响因子：
4.7
通讯作者：
Fabian, Sarah
中科院分区：
文献类型：
--
作者：
Baker, Jason K.;Fenning, Rachel M.;Erath, Stephen A.;Fabian, Sarah
患有自闭症谱系障碍（ASD）的儿童在情绪调节方面遇到了重大困难。理论和经验证据表明，大量的生物学贡献的监管挑战，这可能与核心ASD症状。呼吸窦心律失常（RSA）是副交感神经系统活动的一种测量方法，可作为情绪调节的假定生物标志物。在非临床人群中，更高的基线RSA和更多的RSA反应性（副交感神经退缩; RSA-R）对挑战的反应似乎是适应性的，但ASD儿童的现有证据仍然不确定。目前的研究检查了61名6至10岁ASD儿童中观察到的情绪失调的相关性，包括ASD症状水平以及基线RSA和并发RSA反应性。与先前的研究一致，ASD症状水平与观察到的失调显著相关，而其他因素如儿童智商则不相关。基线RSA与观察到的调节异常无关，但RSA反应性越高，预测并发调节异常的作用就越大，超过了儿童ASD症状的作用。研究结果有助于对这些儿童的调节障碍有一个新的认识，对传统的基线RSA措施在这一人群中的实用性提出了疑问，并澄清了RSA反应作为ASD儿童情绪调节障碍的危险因素的功能意义。患有自闭症谱系障碍（ASD）的儿童有很高的情绪失调风险。这项研究确定了核心ASD症状水平对理解监管挑战很重要，并表明某些生物唤醒过程（例如，调节控制的“释放”以应对挑战）对于这一群体可能以与对于具有神经典型发育的大多数儿童通常观察到的不同的方式起作用。
Children with autism spectrum disorder (ASD) experience significant difficulties with emotion regulation. Theory and empirical evidence suggest substantial biological contributions to regulatory challenges, which may be related to core ASD symptoms. Respiratory sinus arrythmia (RSA) is a measure of parasympathetic nervous system activity that serves as a putative biomarker for emotion regulation. Higher baseline RSA and more RSA reactivity (parasympathetic withdrawal; RSA-R) in response to challenge appear adaptive in non-clinical populations, but existing evidence for children with ASD remains inconclusive. The current study examined correlates of observed emotion dysregulation in 61 children with ASD between the ages of 6 and 10 years, including ASD symptom levels as well as both baseline RSA and concurrent RSA reactivity. Consistent with previous research, ASD symptom level was significantly correlated with observed dysregulation whereas additional factors such as child IQ were not. Baseline RSA was unrelated to observed dysregulation, but higher RSA reactivity predicted concurrent dysregulation above and beyond the contribution of child ASD symptoms. Findings contribute to an emerging understanding of dysregulation in these children, raise questions about the utility of traditional baseline RSA measures for this population, and clarify the functional significance of RSA reactivity as a risk factor for emotion dysregulation in children with ASD. Children with autism spectrum disorder (ASD) are at high risk for emotion dysregulation. This study identifies core ASD symptom level as important to understanding regulatory challenges, and suggests that certain biological arousal processes (e.g., the “freeing” of regulatory control to meet a challenge) may operate in a different way for this population as compared to what is generally observed for most children with neurotypical development.
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