Integrating fasciolosis control in the dry cow management: the effect of closantel treatment on milk production.
Integrating fasciolosis control in the dry cow management: the effect of closantel treatment on milk production.
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DOI：
10.1371/journal.pone.0043216
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Vercruysse J
中科院分区：
文献类型：
--
作者：
Charlier J;Hostens M;Jacobs J;Van Ranst B;Duchateau L;Vercruysse J
肝片形吸虫是反刍动物的寄生虫，在世界范围内分布，在欧盟成员国的发病率明显增加。由于缺乏具有零停乳时间的杀吸虫剂，奶牛中的有效控制受到阻碍，使干奶期成为唯一可以应用预防性治疗的时间。在这里，我们提出了一个双盲，随机和安慰剂对照试验的结果，对11个奶牛群（402头动物）暴露于F。Hepatica，以1）在干乳期（或首次产犊小母牛产犊前80-42天）评估氯氰碘柳胺给药对产奶量参数的影响，2）评价许多易于使用的动物参数是否与给药后的产奶量反应相关。Closantel治疗导致抗F显著降低。从治疗后3-6个月开始，肝抗体水平，较高的峰值产量（1.06公斤）和略高的持久性（9%）的泌乳，导致305天的牛奶产量增加303公斤。驱虫剂处理对牛奶的平均蛋白质和脂肪含量没有影响。给药后，瘦弱动物的产奶量反应较差，在第一次泌乳动物和高（0.3-0.5 ODR）但非极高（≥0.5 ODR）F的奶牛中观察到临床相关的较高产奶量反应。来自前一次泌乳的乳汁样品的肝菌ELISA结果。我们的结论是，在奶牛群暴露于F。因此，在干奶期使用杀吸虫剂是一种有效的策略，可降低接触水平，增加随后的泌乳量。此外，研究结果表明，可以根据易于使用的参数开发仅针对畜群中选定动物的治疗方法。
The liver fluke Fasciola hepatica is a parasite of ruminants with a worldwide distribution and an apparent increasing incidence in EU member states. Effective control in dairy cattle is hampered by the lack of flukicides with a zero-withdrawal time for milk, leaving the dry period as the only time that preventive treatment can be applied. Here, we present the results of a blinded, randomized and placebo-controlled trial on 11 dairy herds (402 animals) exposed to F. hepatica to 1) assess the effect of closantel treatment at dry-off (or 80–42 days before calving in first-calving heifers) on milk production parameters and 2) evaluate if a number of easy-to-use animal parameters is related to the milk production response after treatment. Closantel treatment resulted in a noticeable decrease of anti-F. hepatica antibody levels from 3–6 months after treatment onwards, a higher peak production (1.06 kg) and a slightly higher persistence (9%) of the lactation, resulting in a 305-day milk production increase of 303 kg. No effects of anthelmintic treatment were found on the average protein and fat content of the milk. Milk production responses after treatment were poor in meagre animals and clinically relevant higher milk production responses were observed in first-lactation animals and in cows with a high (0.3–0.5 optical density ratio (ODR)), but not a very high (≥0.5 ODR) F. hepatica ELISA result on a milk sample from the previous lactation. We conclude that in dairy herds exposed to F. hepatica, flukicide treatment at dry-off is a useful strategy to reduce levels of exposure and increase milk production in the subsequent lactation. Moreover, the results suggest that treatment approaches that only target selected animals within a herd can be developed based on easy-to-use parameters.
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