Teneurin-3 controls topographic circuit assembly in the hippocampus.
Teneurin-3 controls topographic circuit assembly in the hippocampus.
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DOI：
10.1038/nature25463
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发表时间：
2018-02-15
期刊：
影响因子：
64.8
通讯作者：
Luo L
中科院分区：
文献类型：
--
作者：
Berns DS;DeNardo LA;Pederick DT;Luo L
大脑功能依赖于特定的连接模式。Teneurins是进化上保守的跨膜蛋白，在果蝇中指导突触伴侣匹配，并且是脊椎动物视觉系统发育所必需的。脊椎动物Teneurins在视觉系统之外的连接中的作用在很大程度上仍然未知，其作用机制尚未得到证实。在这里，我们表明，小鼠Teneurin-3表达在多个地形相互关联的地区的海马区，包括近端CA1，远端下托，内侧内嗅皮质。病毒遗传学分析表明，Teneurin-3是需要在CA1和下托神经元的精确定位近端CA1轴突远端下托。此外，Teneurin-3在体外以剪接异构体依赖性方式促进嗜同性粘附。这些发现表明在多个海马区域中存在显著的遗传异质性，并表明Teneurin-3可能通过匹配表达和同性吸引来协调哺乳动物大脑中复杂分布式电路的组装。
Brain functions rely on specific patterns of connectivity. Teneurins are evolutionarily conserved transmembrane proteins that instruct synaptic partner matching in Drosophila and are required for vertebrate visual system development. The roles of vertebrate Teneurins in connectivity beyond the visual system remain largely unknown and their mechanisms of action have not been demonstrated. Here we show that mouse Teneurin-3 is expressed in multiple topographically interconnected areas of the hippocampal region, including proximal CA1, distal subiculum, and medial entorhinal cortex. Viral-genetic analyses reveal that Teneurin-3 is required in both CA1 and subicular neurons for the precise targeting of proximal CA1 axons to distal subiculum. Furthermore, Teneurin-3 promotes homophilic adhesion in vitro in a splicing isoform-dependent manner. These findings demonstrate striking genetic heterogeneity across multiple hippocampal areas and suggest that Teneurin-3 may orchestrate the assembly of a complex distributed circuit in the mammalian brain via matching expression and homophilic attraction.
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DOI：
10.1016/j.cub.2016.05.035
发表时间：
2016-07-25
期刊：
Current biology : CB
影响因子：
--
作者：
Antinucci P;Suleyman O;Monfries C;Hindges R
通讯作者：
Hindges R
影响因子：
3.7
作者：
Dharmaratne N;Glendining KA;Young TR;Tran H;Sawatari A;Leamey CA
通讯作者：
Leamey CA
影响因子：
64.8
作者：
Hong, Weizhe;Mosca, Timothy J.;Luo, Liqun
通讯作者：
Luo, Liqun
影响因子：
64.5
作者：
Loh, Ken H.;Stawski, Philipp S.;Draycott, Austin S.;Udeshi, Namrata D.;Lehrman, Emily K.;Wilton, Daniel K.;Svinkina, Tanya;Deerinck, Thomas J.;Ellisman, Mark H.;Stevens, Beth;Carr, Steven A.;Ting, Alice Y.
通讯作者：
Ting, Alice Y.
影响因子：
2.5
作者：
Honda, Y;Ishizuka, N
通讯作者：
Ishizuka, N