Systemic Monocytic-MDSCs Are Generated from Monocytes and Correlate with Disease Progression in Breast Cancer Patients.
Systemic Monocytic-MDSCs Are Generated from Monocytes and Correlate with Disease Progression in Breast Cancer Patients.
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DOI：
10.1371/journal.pone.0127028
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Leandersson K
中科院分区：
文献类型：
--
作者：
Bergenfelz C;Larsson AM;von Stedingk K;Gruvberger-Saal S;Aaltonen K;Jansson S;Jernström H;Janols H;Wullt M;Bredberg A;Rydén L;Leandersson K
髓系抑制细胞(MDSCs)是一种高度免疫抑制的髓系细胞，在癌症患者中增加。它们产生和功能背后的分子机制尚不清楚。虽然粒细胞-MDSCs与乳腺癌的总体生存率较低有关，但单核细胞-MDSCs(Mo-MDSCs)的存在和相关性尚不清楚。在这里，我们首次报道了乳腺癌患者在获得典型的Mo-MDSC表型之前，其血液中功能丰富的Mo-MDSC。在疾病进展过程中，具有典型细胞表面表型(CD14+HLA-DRlow/-CD86low/-CD80low/-CD163low/-)的Mo-MDSCs首先显着增加，并与淋巴结和内脏器官的转移相关。此外，转移性乳腺癌患者的单核细胞组成Mo-MDSC群体，无论是在表面和功能表型上，还是在分子基因表达谱上，都与严重感染患者的重编程免疫抑制单核细胞相似。我们的数据表明，监测乳腺癌患者的Mo-MDSC水平可能是评估疾病进展的一种新的、简单的生物标志物。
Myeloid-derived suppressor cells (MDSCs) are highly immunosuppressive myeloid cells, which increase in cancer patients. The molecular mechanism behind their generation and function is unclear. Whereas granulocytic-MDSCs correlate with poor overall survival in breast cancer, the presence and relevance of monocytic-MDSCs (Mo-MDSCs) is unknown. Here we report for the first time an enrichment of functional blood Mo-MDSCs in breast cancer patients before they acquire a typical Mo-MDSC surface phenotype. A clear population of Mo-MDSCs with the typical cell surface phenotype (CD14+HLA-DRlow/-CD86low/-CD80low/-CD163low/-) increased significantly first during disease progression and correlated to metastasis to lymph nodes and visceral organs. Furthermore, monocytes, comprising the Mo-MDSC population, from patients with metastatic breast cancer resemble the reprogrammed immunosuppressive monocytes in patients with severe infections, both by their surface and functional phenotype but also at their molecular gene expression profile. Our data suggest that monitoring the Mo-MDSC levels in breast cancer patients may represent a novel and simple biomarker for assessing disease progression.
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DOI：
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发表时间：
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期刊：
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