Characterization of Ferromagnetic Composite Implants for Tumor Bed Hyperthermia.
Characterization of Ferromagnetic Composite Implants for Tumor Bed Hyperthermia.
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DOI：
10.1109/tmag.2021.3097915
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发表时间：
2021-09
影响因子：
2.1
通讯作者：
Kostin AA
中科院分区：
文献类型：
--
作者：
Osintsev AM;Vasilchenko IL;Rodrigues DB;Stauffer PR;Braginsky VI;Rynk VV;Gromov ES;Prosekov AY;Kaprin AD;Kostin AA
热疗（HT）与放疗或化疗联合治疗癌症已成为公认的方法。有许多方法可以加热肿瘤，最佳方法取决于治疗部位。本研究探讨了一种复合铁磁外科植入物插入肿瘤床提供局部HT。植入物的加热通过感应耦合来自亚兆赫频率的外部磁场的能量来实现。植入物是通过机械填充切除的肿瘤床与自聚合塑料质量混合小铁磁热种子。制造模型植入物，然后在我们自己设计的直径为35 cm的感应线圈中加热。实验结果表明，植入物很容易被加热到允许在频率为90 kHz且振幅不超过4 kA/m的外部磁场中进行传统HT（39-45°C）或热消融治疗（>50°C）的温度。这些结果与使用有限元法求解的电磁和传热组合方程的数值解非常一致。
Hyperthermia therapy (HT) is becoming a well-recognized method for the treatment of cancer when combined with radiation or chemotherapy. There are many ways to heat a tumor and the optimum approach depends on the treatment site. This study investigates a composite ferromagnetic surgical implant inserted in a tumor bed for the delivery of local HT. Heating of the implant is achieved by inductively coupling energy from an external magnetic field of sub-megahertz frequency. Implants are formed by mechanically filling a resected tumor bed with self-polymerizing plastic mass mixed with small ferromagnetic thermoseeds. Model implants were manufactured and then heated in a 35 cm diameter induction coil of our own design. Experimental results showed that implants were easily heated to temperatures that allow either traditional HT (39–45°C) or thermal ablation therapy (>50°C) in an external magnetic field with a frequency of 90 kHz and amplitude not exceeding 4 kA/m. These results agreed well with a numerical solution of combined electromagnetic and heat transfer equations solved using the finite element method.
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影响因子：
3.1
作者：
Frey, Benjamin;Weiss, Eva-Maria;Gaipl, Udo S.
通讯作者：
Gaipl, Udo S.
DOI：
10.1053/ejso.2000.1000
发表时间：
2000-12-01
期刊：
EUROPEAN JOURNAL OF SURGICAL ONCOLOGY
影响因子：
--
作者：
Elias, D;Goharin, A;de Baere, T
通讯作者：
de Baere, T
影响因子：
3.1
作者：
GROSS, EJ;CETAS, TC;LUMORI, MLD
通讯作者：
LUMORI, MLD
影响因子：
0.6
作者：
Brace C
通讯作者：
Brace C
影响因子：
3.8
作者：
BREZOVICH, IA;ATKINSON, WJ;CHAKRABORTY, DP
通讯作者：
CHAKRABORTY, DP