Association of KIR gene polymorphisms with COVID-19 disease.
Association of KIR gene polymorphisms with COVID-19 disease.
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DOI：
10.1016/j.clim.2021.108911
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发表时间：
2022-01
期刊：
影响因子：
--
通讯作者：
Alaamery M
中科院分区：
文献类型：
--
作者：
Hajeer A;Jawdat D;Massadeh S;Aljawini N;Abedalthagafi MS;Arabi YM;Alaamery M
自然杀伤 (NK) 细胞在对抗病毒方面发挥着重要作用。 NK 细胞表达杀伤细胞免疫球蛋白样受体 (KIR)，调节其活性和功能。 KIR 单倍型的多态性赋予不同的病毒易感性和感染引起的疾病严重程度。我们研究了 KIR 基因与 COVID-19 疾病严重程度之间的关联。 424例COVID-19阳性患者根据病情严重程度分为轻度、中度和重度。使用下一代测序 (NGS) 对 KIR 基因进行基因分型。研究人员对 KIR 基因与 COVID-19 疾病严重程度之间的关联进行了研究，并报告了显着相关性。在COVID-19患者中，KIR Bx基因型比AA基因型更常见。 Bx 基因型在轻度疾病患者中更常见，而在重度疾病患者中，AA 基因型比 Bx 基因型更常见。 KIR2DS4 基因严重感染 COVID-19 的风险最高（OR 8.48，pc= 0.0084），其次是 KIR3DL1（OR 7.61，pc= 0.0192）。我们的研究结果表明，KIR2DS4 和 KIR3DL1 基因具有罹患严重 COVID-19 疾病的风险。
Natural killer (NK) cells play an essential role against viruses. NK cells express killer cell immunoglobulin-like receptors (KIRs) which regulate their activity and function. The polymorphisms in KIR haplotypes confer differential viral susceptibility and disease severity caused by infections. We investigated the association between KIR genes and COVID-19 disease severity. 424 COVID-19 positive patients were divided according to their disease severity into mild, moderate and severe. KIR genes were genotyped using next generation sequencing (NGS). Association between KIR genes and COVID-19 disease severity was conducted and significant correlations were reported. In the COVID-19 patients, KIR Bx genotype was more common than AA genotype. The Bx genotype was found more frequently in patients with mild disease, while in severe disease the AA genotype was more common than the Bx genotype. The KIR2DS4 gene carried the highest risk for severe COVID-19 infection (OR 8.48, pc= 0.0084) followed by KIR3DL1 (OR 7.61, pc= 0.0192). Our findings suggest that KIR2DS4 and KIR3DL1 genes carry risk for severe COVID-19 disease.
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