Brain gamma-aminobutyric acid (GABA) abnormalities in bipolar disorder.
Brain gamma-aminobutyric acid (GABA) abnormalities in bipolar disorder.
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DOI：
10.1111/bdi.12074
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发表时间：
2013-06
影响因子：
5.4
通讯作者：
Ongür D
中科院分区：
文献类型：
--
作者：
Brady RO Jr;McCarthy JM;Prescot AP;Jensen JE;Cooper AJ;Cohen BM;Renshaw PF;Ongür D
γ-氨基丁酸（GABA）异常与双相情感障碍有关。然而，由于测量死后、脑脊液、血浆和体内脑GABA水平的研究不一致，这些异常的性质尚不清楚。使用质子磁共振波谱，我们调查了GABA的组织水平在前扣带皮层和顶叶枕叶皮质的参与者与双相情感障碍和健康对照。14名稳定用药的心境正常的门诊I型双相情感障碍患者（平均年龄32.6岁，8名男性）和14名健康对照参与者（平均年龄36.9岁，10名男性）在提供知情同意书后完成了4特斯拉质子磁共振波谱扫描。我们使用MEGAPRESS从两个16.7 mL体素收集数据，并使用LCModel进行分析。与健康对照组相比，双相情感障碍参与者的前扣带回皮质（升高25.1%）和顶枕叶皮质（升高14.6%）的GABA/肌酸比值升高[F = 4.4，p = 0.048]。没有服用GABA调节药物的双相情感障碍参与者表现出比服用GABA调节药物的患者更大的GABA/肌酸升高。我们发现，与健康对照组相比，心境正常的双相情感障碍门诊患者的GABA/肌酸水平较高，这种升高的程度可能受到GABA调节药物的使用的影响。我们的研究结果表明，双相情感障碍患者脑GABA水平升高可能与GABA能功能障碍有关，GABA调节药物可降低这种情况下的GABA水平。
Gamma-aminobutyric acid (GABA) abnormalities have been implicated in bipolar disorder. However, due to discrepant studies measuring postmortem, cerebrospinal fluid, plasma, and in vivo brain levels of GABA, the nature of these abnormalities is unclear. Using proton magnetic resonance spectroscopy, we investigated tissue levels of GABA in the anterior cingulate cortex and parieto-occipital cortex of participants with bipolar disorder and healthy controls. Fourteen stably medicated euthymic outpatients with bipolar disorder type I (mean age 32.6 years, eight male) and 14 healthy control participants (mean age 36.9 years, 10 male) completed a proton magnetic resonance spectroscopy scan at 4-Tesla after providing informed consent. We collected data from two 16.7-mL voxels using MEGAPRESS, and they were analyzed using LCModel. GABA/creatine ratios were elevated in bipolar disorder participants compared to healthy controls [F = 4.4, p = 0.048] in the anterior cingulate cortex (25.1% elevation) and the parieto-occipital cortex (14.6% elevation). Bipolar disorder participants not taking GABA-modulating medications demonstrated greater GABA/creatine elevations than patients taking GABA-modulating medications. We found higher GABA/creatine levels in euthymic bipolar disorder outpatients compared to healthy controls, and the extent of this elevation may be affected by the use of GABA-modulating medications. Our findings suggest that elevated brain GABA levels in bipolar disorder may be associated with GABAergic dysfunction and that GABA-modulating medications reduce GABA levels in this condition.
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