Neurocognitive and neuroimaging predictors of clinical outcome in bipolar disorder.
Neurocognitive and neuroimaging predictors of clinical outcome in bipolar disorder.
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DOI：
10.1007/s11920-010-0151-5
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发表时间：
2010-12
影响因子：
6.7
通讯作者：
Glahn, David C.
中科院分区：
文献类型：
--
作者：
Bearden, Carrie E.;Woogen, Michelle;Glahn, David C.
从历史上看，双相情感障碍一直被认为是一种涉及间歇性而不是慢性功能障碍的疾病。然而，越来越多的证据表明，双相情感障碍与严重的间歇性心理社会和职业损害有关。在这里，我们回顾了神经认知缺陷以及结构和功能神经解剖学改变对观察到的功能障碍的贡献。特别是，现在有令人信服的证据表明，神经认知障碍，特别是在注意力、处理速度和记忆领域，与功能结果有关。尽管双相情感障碍与神经功能障碍的相关性研究还处于初级阶段，但初步证据表明，脑白质异常可能预示着不良预后。更好地了解神经认知和神经成像分析与功能结果之间的关系，有可能改进目前的治疗方案，并为双相情感障碍的新治疗策略提供靶点。
Historically, bipolar disorder has been conceptualized as a disease involving episodic rather than chronic dysfunction. However, increasing evidence indicates that bipolar disorder is associated with substantial inter-episode psychosocial and vocational impairment. Here we review the contributions of neurocognitive deficits and structural and functional neuroanatomic alterations to the observed functional impairments. In particular, compelling evidence now suggests that neurocognitive impairments, particularly in the areas of attention, processing speed, and memory, are associated with functional outcome. Although investigation of the neural correlates of functional disability in bipolar disorder is only in its nascent stages, preliminary evidence suggests that white matter abnormalities may be predictive of poor outcome. A better understanding of the relationship between neurocognitive and neuroimaging assays and functional outcome has the potential to improve current treatment options and provide targets for new treatment strategies in bipolar disorder.
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影响因子：
--
作者：
Glahn, David C.;Almasy, Laura;Barguil, Marcela;Hare, Elizabeth;Peralta, Juan Manuel;Kent, Jack W., Jr.;Dassori, Albana;Contreras, Javier;Pacheco, Adriana;Lanzagorta, Nuria;Nicolini, Humberto;Raventos, Henriette;Escamilla, Michael A.
通讯作者：
Escamilla, Michael A.
影响因子：
5.4
作者：
Martinez-Aran, A.;Vieta, E.;Ayuso-Mateos, J. L.
通讯作者：
Ayuso-Mateos, J. L.
影响因子：
6.7
作者：
Goswami, U.;Sharma, A.;Moore, P. B.
通讯作者：
Moore, P. B.
影响因子：
10.6
作者：
Kieseppä, T;van Erp, TGM;Lönnqvist, J
通讯作者：
Lönnqvist, J
影响因子：
10.6
作者：
Bearden, Carrie E.;Thompson, Paul M.;Soares, Jair C.
通讯作者：
Soares, Jair C.