Plasma levels of prorenin and renin in blacks and whites: their relative abundance and associations with plasma aldosterone concentration.
Plasma levels of prorenin and renin in blacks and whites: their relative abundance and associations with plasma aldosterone concentration.
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黑人和白人的血浆肾素原和肾素水平：它们的相对丰度以及与血浆醛固酮浓度的关联。
DOI：
10.1038/ajh.2012.83
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发表时间：
2012
影响因子：
3.2
通讯作者：
JanDanser,AH
中科院分区：
文献类型：
--
作者：
Tu,Wanzhu;Eckert,GeorgeJ;Pratt,JHoward;JanDanser,AH
背景所有肾素都是由原肾素产生的。肾素与前肾素的比例会影响整体肾素-血管紧张素-醛固酮的活性。方法我们分析了129名年轻黑人和白人的血浆肾素原、肾素和醛固酮水平及其相互作用。结果黑人的血浆肾素浓度(PRC)和肾素活性(PRA)较低，但与白人相似(黑人为69pg/ml，白人为62pg/ml，P=0.41)。结果，黑人的肾素占总肾素的比例显著降低(黑人为11.5%，白人为19.8%；P=0.0001)。由于原肾素也存在于包括肾上腺在内的组织中，在那里它可以与特定的受体结合以产生血管紧张素II，因此我们研究了原肾素水平与血浆醛固酮浓度(PAC)的关系。在黑人和白人中，PAC与Prorenin呈正相关(P=0.04)，而在黑人中，PAC与Prorenin呈负相关(P=0.04)，我们认为这是由于黑人Prorenin向肾素的转化减少所致。然而，这些高循环前肾素水平并不会导致健康年轻黑人的肾上腺血管紧张素II和醛固酮产生增加。美国高血压杂志，2012年6月14日提前在线出版；doi：10.1038/ajh.2012.83
BackgroundAll renin arises from prorenin. The proportion of renin relative to prorenin could influence overall renin–angiotensin–aldosterone activity. We sought to determine whether prorenin levels were related to extracellular volume, as reflected by the levels of plasma renin activity (PRA), and to aldosterone.MethodsWe analyzed plasma levels of prorenin, renin, and aldosterone, as well as their interactions, in 129 young blacks and whites.ResultsBlacks had lower plasma renin concentration (PRC) and PRA, but had prorenin levels similar to whites (69 pg/ml in blacks vs. 62 pg/ml in whites,P= 0.41). As a result, the renin-to-total renin ratio was significantly lower in blacks (11.5% in blacks as compared to 19.8% in whites;P= 0.0001). Because prorenin also resides in tissues including the adrenal where it can bind to a specific receptor to generate angiotensin II, we examined the relationship of prorenin levels to plasma aldosterone concentrations (PAC). While a positive association between PRC and PAC was found in both blacks and whites, PAC was positively related to prorenin in whites (P= 0.04) but negatively in blacks, an observation that we hypothesize was due to reduced prorenin-to-renin conversion in blacks.ConclusionsWe observed a disproportionately high level of prorenin in blacks. These high circulating prorenin levels however do not result in greater adrenal angiotensin II and aldosterone production in healthy young blacks.American Journal of Hypertension, advance online publication 14 June 2012; doi:10.1038/ajh.2012.83
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影响因子：
9.1
作者：
Helmer, O M
通讯作者：
Helmer, O M
影响因子：
19.6
作者：
Kaneshiro, Y.;Ichihara, A.;Inagami, T.
通讯作者：
Inagami, T.
刺激人肾素原受体直接增加血浆醛固酮水平
DOI：
--
发表时间：
2006
期刊：
影响因子：
--
作者：
M.;Sakoda;T.Takemitsu;M.Sakoda;T.Takemitsu;H.Takahashi;AHM.Nurun Nabi;M.Sakoda;K.Inomata
通讯作者：
K.Inomata
影响因子：
2.6
作者：
Ott, Christian;Schneider, Markus P.;Schmieder, Roland E.
通讯作者：
Schmieder, Roland E.
血压正常的白人和黑人受试者对钠给药的反应存在差异。
DOI：
--
发表时间：
1977
期刊：
Journal of Laboratory and Clinical Medicine
影响因子：
--
作者：
F. Luft;C. Grim;J. T. Higgins;M. Weinberger
通讯作者：
M. Weinberger