Longitudinal changes in task-evoked brain responses in Parkinson's disease patients with and without mild cognitive impairment.
Longitudinal changes in task-evoked brain responses in Parkinson's disease patients with and without mild cognitive impairment.
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DOI：
10.3389/fnins.2014.00207
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发表时间：
2014
影响因子：
4.3
通讯作者：
Nyberg L
中科院分区：
文献类型：
--
作者：
Ekman U;Eriksson J;Forsgren L;Domellöf ME;Elgh E;Lundquist A;Nyberg L
认知缺陷在帕金森病中很常见。先前的横断面研究已经证明认知障碍与额纹状体多巴胺能失调之间存在联系。然而，缺乏将疾病进展与任务诱发的大脑活动改变联系起来的纵向研究。因此，我们的目标是纵向评估患有或不患有轻度认知障碍（MCI）的帕金森病患者与工作记忆相关的大脑活动变化。患者是在特发性帕金森病患者的纵向队列研究中招募的。我们纵向（在基线检查和 12 个月随访时）比较了 28 名不伴有 MCI 的帕金森病患者与 11 名患有帕金森病和 MCI 的患者。在言语双背工作记忆任务中测量功能性 MRI 血氧水平依赖性信号。两个时间点均出现 MCI 的患者双侧内侧前额叶皮层募集不足（组的主要效应：p < 0.001，未校正）。重要的是，在右侧梭状回中发现了显着的按时间分组的交互效应（p < 0.001，未校正），这表明在基线和随访期间，患有帕金森病和 MCI 的患者的工作记忆相关活动有所下降，而没有 MCI 的患者在各个时间点上保持稳定。相对于患有 MCI 的患者，无 MCI 的患者右侧梭状回和双侧尾状核之间的功能连接更强。我们的研究结果支持这样的观点，即工作记忆更新缺陷与早期帕金森病和 MCI 患者持续的额叶纹状体募集不足有关。帕金森病中 MCI 的纵向演变转化为额外的任务诱发的后皮质变化。
Cognitive deficits are common in Parkinson's disease. Previous cross-sectional research has demonstrated a link between cognitive impairments and fronto-striatal dopaminergic dysmodulation. However, longitudinal studies that link disease progression with altered task-evoked brain activity are lacking. Therefore, our objective was to longitudinally evaluate working-memory related brain activity changes in Parkinson's disease patients with and without mild cognitive impairment (MCI). Patients were recruited within a longitudinal cohort study of incident patients with idiopathic parkinsonism. We longitudinally (at baseline examination and at 12-months follow-up) compared 28 patients with Parkinson's disease without MCI with 11 patients with Parkinson's disease and MCI. Functional MRI blood oxygen level dependent signal was measured during a verbal two-back working-memory task. Patients with MCI under-recruited bilateral medial prefrontal cortex at both time-points (main effect of group: p < 0.001, uncorrected). Critically, a significant group-by-time interaction effect (p < 0.001, uncorrected) was found in the right fusiform gyrus, indicating that working-memory related activity decreased for patients with Parkinson's disease and MCI between baseline and follow-up, while patients without MCI were stable across time-points. The functional connectivity between right fusiform gyrus and bilateral caudate nucleus was stronger for patients without MCI relative to patients with MCI. Our findings support the view that deficits in working-memory updating are related to persistent fronto-striatal under-recruitments in patients with early phase Parkinson's disease and MCI. The longitudinal evolution of MCI in Parkinson's disease translates into additional task-evoked posterior cortical changes.
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影响因子：
9.9
作者：
Hilker, R;Thomas, AV;Heiss, WD
通讯作者：
Heiss, WD
影响因子：
8.6
作者：
Marsh, Laura;Biglan, Kevin;Gerstenhaber, Melissa;Williams, James R.
通讯作者：
Williams, James R.
影响因子：
4.1
作者：
Burgess, Gregory C.;Gray, Jeremy R.;Braver, Todd S.
通讯作者：
Braver, Todd S.
影响因子：
5.7
作者：
Chang, Catherine;Crottaz-Herbette, Sonia;Menon, Vinod
通讯作者：
Menon, Vinod
影响因子：
2.4
作者：
Lyoo, Chul Hyoung;Jeong, Yong;Lee, Myung Sik
通讯作者：
Lee, Myung Sik