The EU Child Cohort Network's core data: establishing a set of findable, accessible, interoperable and re-usable (FAIR) variables.
The EU Child Cohort Network's core data: establishing a set of findable, accessible, interoperable and re-usable (FAIR) variables.
复制标题
DOI：
10.1007/s10654-021-00733-9
复制
发表时间：
2021-05
影响因子：
13.6
通讯作者：
LifeCycle Project Group
中科院分区：
文献类型：
--
作者：
Pinot de Moira A;Haakma S;Strandberg-Larsen K;van Enckevort E;Kooijman M;Cadman T;Cardol M;Corpeleijn E;Crozier S;Duijts L;Elhakeem A;Eriksson JG;Felix JF;Fernández-Barrés S;Foong RE;Forhan A;Grote V;Guerlich K;Heude B;Huang RC;Järvelin MR;Jørgensen AC;Mikkola TM;Nader JLT;Pedersen M;Popovic M;Rautio N;Richiardi L;Ronkainen J;Roumeliotaki T;Salika T;Sebert S;Vinther JL;Voerman E;Vrijheid M;Wright J;Yang TC;Zariouh F;Charles MA;Inskip H;Jaddoe VWV;Swertz MA;Nybo Andersen AM;LifeCycle Project Group
Horizon 2020生命周期项目是一个跨队列合作项目，汇集了来自欧洲和澳大利亚的多个出生队列的数据，以促进对生命早期暴露对后期健康结果影响的研究。这一合作的一个主要成果是建立了一个称为欧盟儿童队列网络的FAIR（可查找、可访问、可互操作和可重复使用）数据资源。在这里，我们重点关注欧盟儿童队列网络的核心变量。这些是一组基本变量，可由大多数参与队列导出，并经常用作生命过程研究中的协变量或暴露量。首先，我们描述了核心变量列表的建立过程。其次，我们解释的协议，根据这些变量进行了协调，以使它们具有互操作性。第三，我们描述了目录，以确保网络的数据是可查找和可重用的。最后，我们描述了核心数据，包括每个队列协调变量的比例和可获得协调核心数据的儿童数量。欧盟儿童队列网络的数据将使用一个联合分析平台进行分析，消除了物理传输数据的需要，从而使研究人员更容易获得数据。该网络将通过增加统计功效和暴露异质性，以及促进跨队列比较、交叉验证和复制，为参与队列增加价值。我们的目标是激励其他队列加入网络，并鼓励更广泛的研究界使用欧盟儿童队列网络。在线版本包含补充材料，可通过10.1007/s10654-021-00733-9获得。
The Horizon2020 LifeCycle Project is a cross-cohort collaboration which brings together data from multiple birth cohorts from across Europe and Australia to facilitate studies on the influence of early-life exposures on later health outcomes. A major product of this collaboration has been the establishment of a FAIR (findable, accessible, interoperable and reusable) data resource known as the EU Child Cohort Network. Here we focus on the EU Child Cohort Network’s core variables. These are a set of basic variables, derivable by the majority of participating cohorts and frequently used as covariates or exposures in lifecourse research. First, we describe the process by which the list of core variables was established. Second, we explain the protocol according to which these variables were harmonised in order to make them interoperable. Third, we describe the catalogue developed to ensure that the network’s data are findable and reusable. Finally, we describe the core data, including the proportion of variables harmonised by each cohort and the number of children for whom harmonised core data are available. EU Child Cohort Network data will be analysed using a federated analysis platform, removing the need to physically transfer data and thus making the data more accessible to researchers. The network will add value to participating cohorts by increasing statistical power and exposure heterogeneity, as well as facilitating cross-cohort comparisons, cross-validation and replication. Our aim is to motivate other cohorts to join the network and encourage the use of the EU Child Cohort Network by the wider research community. The online version contains supplementary material available at 10.1007/s10654-021-00733-9.
登录
查看更多内容
影响因子：
64.8
作者：
Horikoshi, Momoko;Beaumont, Robin N.;Day, Felix R.;Warrington, Nicole M.;Kooijman, Marjolein N.;Fernandez-Tajes, Juan;Feenstra, Bjarke;van Zuydam, Natalie R.;Gaulton, Kyle J.;Grarup, Niels;Bradfield, Jonathan P.;Strachan, David P.;Li-Gao, Ruifang;Ahluwalia, Tarunveer S.;Kreiner, Eskil;Rueedi, Rico;Lyytikainen, Leo-Pekka;Cousminer, Diana L.;Wu, Ying;Thiering, Elisabeth;Wang, Carol A.;Have, Christian T.;Hottenga, Jouke-Jan;Vilor-Tejedor, Natalia;Joshi, Peter K.;Boh, Eileen Tai Hui;Ntalla, Ioanna;Pitkanen, Niina;Mahajan, Anubha;van Leeuwen, Elisabeth M.;Joro, Raimo;Lagou, Vasiliki;Nodzenski, Michael;Diver, Louise A.;Zondervan, Krina T.;Bustamante, Mariona;Marques-Vidal, Pedro;Mercader, Josep M.;Bennett, Amanda J.;Rahmioglu, Nilufer;Nyholt, Dale R.;Ma, Ronald C. W.;Tam, Claudia H. T.;Tam, Wing Hung;Ganesh, Santhi K.;van Rooij, Frank J. A.;Jones, Samuel E.;Loh, Po-Ru;Ruth, Katherine S.;Tuke, Marcus A.;Tyrrell, Jessica;Wood, Andrew R.;Yaghootkar, Hanieh;Scholtens, Denise M.;Paternoster, Lavinia;Prokopenko, Inga;Kovacs, Peter;Atalay, Mustafa;Willems, Sara M.;Panoutsopoulou, Kalliope;Wang, Xu;Carstensen, Lisbeth;Geller, Frank;Schraut, Katharina E.;Murcia, Mario;van Beijsterveldt, Catharina E. M.;Willemsen, Gonneke;Appel, Emil V. R.;Fonvig, Cilius E.;Trier, Caecilie;Tiesler, Carla M. T.;Standl, Marie;Kutalik, Zoltan;Bonas-Guarch, Silvia;Hougaard, David M.;Sanchez, Friman;Torrents, David;Waage, Johannes;Hollegaard, Mads V.;de Haan, Hugoline G.;Rosendaal, Frits R.;Medina-Gomez, Carolina;Ring, Susan M.;Hemani, Gibran;McMahon, George;Robertson, Neil R.;Groves, Christopher J.;Langenberg, Claudia;Luan, Jian'an;Scott, Robert A.;Zhao, Jing Hua;Mentch, Frank D.;MacKenzie, Scott M.;Reynolds, Rebecca M.;Lowe, William L.;Toenjes, Anke;Stumvoll, Michael;Lindi, Virpi;Lakka, Timo A.;van Duijn, Cornelia M.;Kiess, Wieland;Koerner, Antje;Sorensen, Thorkild I. A.;Niinikoski, Harri;Pahkala, Katja;Raitakari, Olli T.;Zeggini, Eleftheria;Dedoussis, George V.;Teo, Yik-Ying;Saw, Seang-Mei;Melbye, Mads;Campbell, Harry;Wilson, James F.;Vrijheid, Martine;de Geus, Eco J. C. N.;Boomsma, Dorret I.;Kadarmideen, Haja N.;Holm, Jens-Christian;Hansen, Torben;Sebert, Sylvain;Hattersley, Andrew T.;Beilin, Lawrence J.;Newnham, John P.;Pennell, Craig E.;Heinrich, Joachim;Adair, Linda S.;Borja, Judith B.;Mohlke, Karen L.;Eriksson, Johan G.;Widen, Elisabeth;Kahonen, Mika;Viikari, Jorma S.;Lehtimaki, Terho;Vollenweider, Peter;Bonnelykke, Klaus;Bisgaard, Hans;Mook-Kanamori, Dennis O.;Hofman, Albert;Rivadeneira, Fernando;Uitterlinden, Andre G.;Pisinger, Charlotta;Pedersen, Oluf;Power, Christine;Hyppoenen, Elina;Wareham, Nicholas J.;Hakonarson, Hakon;Davies, Eleanor;Walker, Brian R.;Jaddoe, Vincent W. V.;Jaervelin, Marjo-Riitta;Grant, Struan F. A.;Vaag, Allan A.;Lawlor, Debbie A.;Frayling, Timothy M.;Smith, George Davey;Morris, Andrew P.;Ong, Ken K.;Felix, Janine F.;Timpson, Nicholas J.;Perry, John R. B.;Evans, David M.;McCarthy, Mark I.;Freathy, Rachel M.
通讯作者：
Freathy, Rachel M.
影响因子：
4.4
作者：
Casas, Maribel;den Dekker, Herman T.;Duijts, Liesbeth
通讯作者：
Duijts, Liesbeth
影响因子：
13.6
作者：
Jaddoe, Vincent W. V.;van Duijn, Cornelia M.;Hofman, Albert
通讯作者：
Hofman, Albert
影响因子：
2.3
作者：
Doiron D;Burton P;Marcon Y;Gaye A;Wolffenbuttel BHR;Perola M;Stolk RP;Foco L;Minelli C;Waldenberger M;Holle R;Kvaløy K;Hillege HL;Tassé AM;Ferretti V;Fortier I
通讯作者：
Fortier I
影响因子：
13.6
作者：
Jaddoe, Vincent W. V.;Felix, Janine F.;Duijts, Liesbeth
通讯作者：
Duijts, Liesbeth