Resolution-enhanced OCT and expanded framework of information capacity and resolution in coherent imaging.
Resolution-enhanced OCT and expanded framework of information capacity and resolution in coherent imaging.
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DOI：
10.1038/s41598-021-99889-3
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发表时间：
2021-10-15
影响因子：
4.6
通讯作者：
Adie SG
中科院分区：
文献类型：
--
作者：
Leartprapun N;Adie SG
传统上，我们将空间分辨率作为光学系统的固定参数进行处理，我们提出了一种方法，以增强光束扫描的光学相干断层扫描（OCT）的横向分辨率，超出了其异常的限制，而不是基于信息的能力（RECORISE of SORVETION）的信息。 （SNR）通过平均抑制有效的噪声和简单的计算带宽扩展程序，我们证明了1.5倍的分辨率相对于无像差的限制，同时在硅胶中保持了相当的SNR。要求域导致在全球大多数OCT系统上，可以很容易地实现信息能力和分辨率的扩展框架，从而有助于相干成像理论。
Spatial resolution in conventional optical microscopy has traditionally been treated as a fixed parameter of the optical system. Here, we present an approach to enhance transverse resolution in beam-scanned optical coherence tomography (OCT) beyond its aberration-free resolution limit, without any modification to the optical system. Based on the theorem of invariance of information capacity, resolution-enhanced (RE)-OCT navigates the exchange of information between resolution and signal-to-noise ratio (SNR) by exploiting efficient noise suppression via coherent averaging and a simple computational bandwidth expansion procedure. We demonstrate a resolution enhancement of 1.5 × relative to the aberration-free limit while maintaining comparable SNR in silicone phantom. We show that RE-OCT can significantly enhance the visualization of fine microstructural features in collagen gel and ex vivo mouse brain. Beyond RE-OCT, our analysis in the spatial-frequency domain leads to an expanded framework of information capacity and resolution in coherent imaging that contributes new implications to the theory of coherent imaging. RE-OCT can be readily implemented on most OCT systems worldwide, immediately unlocking information that is beyond their current imaging capabilities, and so has the potential for widespread impact in the numerous areas in which OCT is utilized, including the basic sciences and translational medicine.
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影响因子：
3.6
作者：
Graf BW;Adie SG;Boppart SA
通讯作者：
Boppart SA
影响因子：
35
作者：
通讯作者：
--
影响因子：
3.6
作者：
Hillmann, Dierck;Pfaeffle, Clara;Huettmann, Gereon
通讯作者：
Huettmann, Gereon
影响因子：
3.4
作者：
Baumann, Bernhard;Merkle, Conrad W.;Hitzenberger, Christoph
通讯作者：
Hitzenberger, Christoph
影响因子：
3.8
作者：
Goldberg, Brian D.;Vakoc, Benjamin J.;Tearney, Guillermo J.
通讯作者：
Tearney, Guillermo J.