White matter diffusion alterations in normal women at risk of Alzheimer's disease.
White matter diffusion alterations in normal women at risk of Alzheimer's disease.
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DOI：
10.1016/j.neurobiolaging.2008.08.006
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发表时间：
2010-07
影响因子：
4.2
通讯作者：
Gold, Brian T.
中科院分区：
文献类型：
--
作者：
Smith, Charles D.;Chebrolu, Himachandra;Andersen, Anders H.;Powell, David A.;Lovell, Mark A.;Xiong, Shuling;Gold, Brian T.
关键词：
在被诊断患有轻度认知障碍（MCI）和阿尔茨海默病（AD）的受试者中观察到白色物质平均扩散率增加和各向异性分数（FA）降低。我们试图确定在有AD风险的正常个体中是否发生类似的白色物质改变。扩散张量图像采集42认知正常的右利手的女性都有痴呆症家族史和至少一个载脂蛋白E4等位基因。将这些图像与23名无AD危险因素的正常女性的图像进行比较。组分析进行了基于轨道的空间统计。在额枕和颞下束（特别是后部）、胼胝体压部、胼胝体下白色物质和扣带束中观察到FA减少。这些研究结果表明，特定的白色物质通路在AD风险增加的正常女性中在预期的认知症状发作前数年发生改变。
Increased white matter mean diffusivity and decreased fractional anisotropy (FA) has been observed in subjects diagnosed with mild cognitive impairment (MCI) and Alzheimer's disease (AD). We sought to determine whether similar alterations of white matter occur in normal individuals at risk of AD. Diffusion tensor images were acquired in 42 cognitively normal right-handed women with both a family history of dementia and at least one apolipoprotein E4 allele. These were compared with images from 23 normal women without either AD risk factor. Group analyses were performed using tract-based spatial statistics. Reduced FA was observed in the fronto-occipital and inferior temporal fasciculi (particularly posteriorly), the splenium of the corpus callosum, subcallosal white matter and the cingulum bundle. These findings demonstrate that specific white matter pathways are altered in normal women at increased risk of AD years before the expected onset of cognitive symptoms.
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影响因子：
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通讯作者：
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