Induction of microRNA‑let‑7a inhibits lung adenocarcinoma cell growth by regulating cyclin D1.
Induction of microRNA‑let‑7a inhibits lung adenocarcinoma cell growth by regulating cyclin D1.
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microRNA-let-7a的诱导通过调节细胞周期蛋白D1抑制肺腺癌细胞生长
DOI：
10.3892/or.2018.6593
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发表时间：
2018-10
期刊：
影响因子：
4.2
通讯作者：
Xie SY
中科院分区：
文献类型：
--
作者：
Zhao W;Hu JX;Hao RM;Zhang Q;Guo JQ;Li YJ;Xie N;Liu LY;Wang PY;Zhang C;Xie SY
肺癌是癌症相关死亡的最常见原因。microRNAs（miRNAs）作为癌基因或抑癌基因，不仅在肿瘤的发生发展中起重要作用，而且在肿瘤的侵袭和转移中也起重要作用。虽然miRNA-let-7a（let-7a）已被报道在多种癌症类型中抑制细胞生长，但let-7a在肺腺癌中的生物学机制尚未完全阐明。本研究通过检测let-7a在肺腺癌组织中的表达，探讨let-7a在肺癌细胞增殖调控中的作用，探讨let-7a在肺腺癌中的分子作用。Let-7a在肺腺癌组织中的表达较正常肺组织明显下调。过表达let-7a可有效抑制H1299和A549细胞的增殖、迁移和侵袭。Let-7a还诱导细胞凋亡和细胞周期阻滞。let-7a通过直接调节细胞周期蛋白D1信号而显著抑制细胞生长。let-7a在肺腺癌中的这种新的调控机制为肺癌的靶向治疗提供了可能的途径。
Lung cancer is the most common cause of cancer-associated mortality. MicroRNAs (miRNAs), as oncogenes or tumor suppressor genes, serve crucial roles not only in tumorigenesis, but also in tumor invasion and metastasis. Although miRNA-let-7a (let-7a) has been reported to suppress cell growth in multiple cancer types, the biological mechanisms of let-7a in lung adenocarcinoma are yet to be fully elucidated. In the present study, the molecular roles of let-7a in lung adenocarcinoma were investigated by detecting its expression in lung adenocarcinoma tissues and exploring its roles in the regulation of lung cancer cell proliferation. Let-7a expression was identified to be downregulated in lung adenocarcinoma tissues compared with normal tissues. Overexpression of let-7a effectively suppressed cancer cell proliferation, migration and invasion in H1299 and A549 cells. Let-7a also induced cell apoptosis and cell cycle arrest. Furthermore, let-7a significantly inhibited cell growth by directly regulating cyclin D1 signals. This novel regulatory mechanism of let-7a in lung adenocarcinoma provides possible avenues for future targeted therapies of lung cancer.
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