Association between a genetic index for lameness resistance and the incidence of claw horn lesions in Holstein cows.
Association between a genetic index for lameness resistance and the incidence of claw horn lesions in Holstein cows.
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荷斯坦奶牛抗跛行遗传指数与爪角病变发生率之间的关联。
DOI：
10.1002/vetr.1632
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Barden M
中科院分区：
文献类型：
--
作者：
Barden M
背景本研究旨在确定跛行优势遗传指数与四种结果之间的关联：鞋底出血 (SH)、鞋底溃疡 (SU)、白线病变 (WL) 和活动评分期间的跛行。方法我们从英国四个主要饲养的奶牛群中招募了 2352 头荷斯坦奶牛。从产犊前到泌乳后期，在四个时间点对奶牛进行活动度评分并记录足部病变。根据国家遗传评估，对奶牛进行基因分型，并为每头奶牛分配遗传指数。对 2107 头奶牛的跛行记录和遗传指数进行了匹配。使用四个独立的多变量逻辑回归模型（包括农场和胎次作为协变量）来量化跛行优势指数与动物是否受到 SH、SU、WL 或跛行的影响之间的关联。结果 跛行优势指数增加一个点的比值比（95% 置信区间）为 0.79 (0.72–0.86)、0.68 (0.59–0.78)、 SH、SU、WL 和跛行分别为 0.94 (0.84–1.04) 和 0.82 (0.74–0.91)。当用公牛的跛行优势指数代替动物自身的跛行优势指数进行评估时，出现了相同的趋势，尽管这种关联的强度通常较弱。 结论 跛行优势指数与 SH、SU 和跛行相关，因此可以考虑在牛群中选择跛行优势指数，以减少跛行。在未对小母牛进行基因组检测的情况下，父系跛行优势指数可能仍能有效降低 SH 和 SU 的发生率。
BackgroundThis study aimed to determine the association between the lameness advantage genetic index and four outcomes: sole haemorrhage (SH), sole ulcers (SU), white line lesions (WL), and lameness during mobility scoring.MethodsWe enrolled 2352 Holstein cows from four predominantly housed dairy herds in the UK. Cows were mobility scored and foot lesions recorded at four time points from before calving to late lactation. Cows were genotyped and genetic indexes were assigned to each cow following national genetic evaluations. Lameness records and genetic indexes were matched for 2107 cows. Four separate multivariable logistic regression models, which included farm and parity as covariables, were used to quantify the association between the lameness advantage index and whether animals were affected by SH, SU, WL, or lameness.ResultsThe odds ratios (95% confidence intervals) for one‐point increases in the lameness advantage index were 0.79 (0.72–0.86), 0.68 (0.59–0.78), 0.94 (0.84–1.04), and 0.82 (0.74–0.91) for SH, SU, WL, and lameness, respectively. The same trends were present when the sire's lameness advantage index was evaluated in place of the animal's own, although the strength of this association was generally weaker.ConclusionThe lameness advantage index is associated with SH, SU, and lameness, therefore selection on the lameness advantage index could be considered in herds aiming to reduce lameness. Where genomic testing of heifers is not conducted, sire lameness advantage index may still be effective to reduce SH and SU incidence.
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作者：
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DOI：
--
发表时间：
1997
期刊：
影响因子：
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作者：
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影响因子：
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作者：
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