Polarity and endocytosis: reciprocal regulation.

Polarity and endocytosis: reciprocal regulation.
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DOI:
10.1016/j.tcb.2010.04.003
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发表时间:
2010-08
影响因子:
19
通讯作者:
Skop AR
Skop AR
中科院分区:
生物学1区
文献类型:
--
作者:
Shivas JM;Morrison HA;Bilder D;Skop AR

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极化质膜结构域的建立和维持对于细胞功能和生物体的正常发育至关重要。参与确定细胞极性的分子和途径在动物物种之间非常保守。从历史上看,胞吐机制在负责细胞极化的运输途径中受到了主要重视。现在越来越多的证据表明,内吞作用在关键极性蛋白的正确定位中发挥着同样重要的作用。有趣的是,一些极性蛋白也可以调节内吞机制。在这里,我们回顾了极性蛋白和内吞途径之间相互调节的新证据,并讨论了这些不同过程如何相互作用以创建单独的细胞域的可能模型。
The establishment and maintenance of polarized plasma membrane domains is essential for cellular function and proper development of organisms. The molecules and pathways involved in determining cell polarity are remarkably well conserved between animal species. Historically, exocytic mechanisms have received primary emphasis amongst trafficking routes responsible for cell polarization. Accumulating evidence now reveals that endocytosis plays an equally important role in the proper localization of key polarity proteins. Intriguingly, some polarity proteins can also regulate the endocytic machinery. Here we review emerging evidence for the reciprocal regulation between polarity proteins and endocytic pathways, and discuss possible models for how these distinct processes could interact to create separate cellular domains.
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