Intermittent cold exposure enhances fat accumulation in mice.
Intermittent cold exposure enhances fat accumulation in mice.
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DOI：
10.1371/journal.pone.0096432
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Shao J
中科院分区：
文献类型：
--
作者：
Yoo HS;Qiao L;Bosco C;Leong LH;Lytle N;Feng GS;Chi NW;Shao J
由于其高能量消耗的特性，棕色脂肪组织（BAT）被认为是能量代谢的关键参与者。冷暴露是BAT的生理激活因子。间歇性冷暴露（ICE）不同于持续暴露，在临床上是可行的。本研究的主要目的是研究ICE是否能减少C57BL/6小鼠的肥胖。令人惊讶的是，我们发现ICE实际上增加了脂肪，尽管增强了BAT中Ucp1的表达，并在皮下白色脂肪组织中诱导了米色脂肪细胞。ICE没有改变基础的全身胰岛素敏感性，但它增加了肝脏甘油三酯含量和分泌率以及血液甘油三酯水平。基因谱分析进一步表明，尽管ICE在冷暴露期间抑制白色脂肪组织和肝脏中的脂肪生成基因表达，但在暴露期间却增强了脂肪生成。总之，我们的研究结果表明，尽管增强了BAT的募集，ICE在小鼠中通过刺激新生脂肪生成来增加脂肪积累。
Due to its high energy consuming characteristics, brown adipose tissue (BAT) has been suggested as a key player in energy metabolism. Cold exposure is a physiological activator of BAT. Intermittent cold exposure (ICE), unlike persistent exposure, is clinically feasible. The main objective of this study was to investigate whether ICE reduces adiposity in C57BL/6 mice. Surprisingly, we found that ICE actually increased adiposity despite enhancing Ucp1 expression in BAT and inducing beige adipocytes in subcutaneous white adipose tissue. ICE did not alter basal systemic insulin sensitivity, but it increased liver triglyceride content and secretion rate as well as blood triglyceride levels. Gene profiling further demonstrated that ICE, despite suppressing lipogenic gene expression in white adipose tissue and liver during cold exposure, enhanced lipogenesis between the exposure periods. Together, our results indicate that despite enhancing BAT recruitment, ICE in mice increases fat accumulation by stimulating de novo lipogenesis.
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影响因子：
3.7
作者：
Baglioni S;Cantini G;Poli G;Francalanci M;Squecco R;Di Franco A;Borgogni E;Frontera S;Nesi G;Liotta F;Lucchese M;Perigli G;Francini F;Forti G;Serio M;Luconi M
通讯作者：
Luconi M
影响因子：
2.9
作者：
KAWATE, R;TALAN, MI;ENGEL, BT
通讯作者：
ENGEL, BT
影响因子：
56.9
作者：
Haemmerle, G;Lass, A;Zechner, R
通讯作者：
Zechner, R
影响因子：
3.7
作者：
Ravussin Y;Xiao C;Gavrilova O;Reitman ML
通讯作者：
Reitman ML
影响因子：
29
作者：
Ohno H;Shinoda K;Spiegelman BM;Kajimura S
通讯作者：
Kajimura S