Revised criteria for mild cognitive impairment may compromise the diagnosis of Alzheimer disease dementia.
Revised criteria for mild cognitive impairment may compromise the diagnosis of Alzheimer disease dementia.
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DOI：
10.1001/archneurol.2011.3152
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发表时间：
2012-06
影响因子：
--
通讯作者：
Morris, John C.
中科院分区：
文献类型：
--
作者：
Morris, John C.
旨在评估由美国国家老龄化研究所和阿尔茨海默病协会赞助的工作组制定的修订后的轻度认知障碍 (MCI) 标准对诊断极轻度和轻度阿尔茨海默病 (AD) 痴呆的潜在影响。对跨诊断类别的功能障碍评级进行回顾性审查。参与者：在阿尔茨海默病中心接受评估并提交给国家阿尔茨海默病协调中心的认知正常、MCI 或 AD 痴呆的个体 (N = 17,535) 的功能评级根据修订标准允许的“功能独立性”定义进行评估。使用连续变量的 t 检验和分类变量的卡方检验 3 个诊断组之间的成对人口统计学差异。目前几乎所有 (99.8%) 被诊断为极轻度 AD 痴呆的个体以及绝大多数 (92.7%) 被诊断为轻度 AD 痴呆的个体均可根据修订后的标准，根据其在社区和家庭日常生活工具性活动的临床痴呆评级领域中的受损程度，重新分类为 MCI。根据功能评估问卷的测量，这些 AD 痴呆症患者中很大一部分也符合修订后的 MCI“功能独立”标准。修订后的标准削弱了 MCI 和阿尔茨海默痴呆轻度阶段之间的分类区别。由此产生的诊断重叠支持这样的前提：“AD 引起的 MCI”代表 AD 的最早症状阶段。
To evaluate the potential impact of revised criteria for mild cognitive impairment (MCI), developed by a Workgroup sponsored by the National Institute on Aging and the Alzheimer’s Association, on the diagnosis of very mild and mild Alzheimer disease (AD) dementia. Retrospective review of ratings of functional impairment across diagnostic categories. Participants: The functional ratings of individuals (N = 17,535) with normal cognition, MCI, or AD dementia who were evaluated at Alzheimer’s Disease Centers and submitted to the National Alzheimer’s Coordinating Center were assessed in accordance with the definition of “functional independence” allowed by the revised criteria. Pairwise demographic differences between the 3 diagnostic groups were tested using t-tests for continuous variables and chi-square for categorical variables. Almost all (99.8%) of individuals currently diagnosed with very mild AD dementia and the large majority (92.7%) of those diagnosed with mild AD dementia could be reclassified as MCI with the revised criteria, based on their level of impairment in the Clinical Dementia Rating domains for performance of instrumental activities of daily living in the community and at home. Large percentages of these AD dementia individuals also meet the revised “functional independence” criterion for MCI as measured by the Functional Assessment Questionnaire. The categorical distinction between MCI and milder stages of Alzheimer dementia has been compromised by the revised criteria. The resulting diagnostic overlap supports the premise that “MCI due to AD” represents the earliest symptomatic stage of AD.
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影响因子：
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作者：
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通讯作者：
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FLICKER, C;FERRIS, SH;REISBERG, B
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作者：
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通讯作者：
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