Early life precursors, epigenetics, and the development of food allergy.
Early life precursors, epigenetics, and the development of food allergy.
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DOI：
10.1007/s00281-012-0323-y
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发表时间：
2012-09
影响因子：
9
通讯作者：
Wang, Xiaobin
中科院分区：
文献类型：
--
作者：
Hong, Xiumei;Wang, Xiaobin
食物过敏（FA）是一个全球性的主要临床和公共卫生问题，由环境暴露、遗传变异、基因-环境相互作用和表观遗传改变的复杂相互作用引起。本文综述了这些关键因素的最新进展，特别关注表观遗传学在FA发展中的潜在作用。流行病学研究报告了许多可能影响FA风险的非遗传因素，如食物引入时间和喂养模式、饮食/营养、暴露于环境烟草吸烟、早产和低出生体重、微生物暴露和种族/民族。目前对FA遗传学的研究主要采用候选基因的方法进行，已经有10多个基因与FA的遗传易感性相关。关于FA的基因-环境互作的研究非常有限。表观遗传改变被认为是介导早期环境暴露和基因-环境相互作用对以后疾病发展的影响的机制之一。本文就表观遗传学在免疫系统调节中的作用以及某些FA相关环境暴露的表观遗传效应进行了综述。特别缺乏同时评估早期生活暴露、遗传易感性、表观基因组改变和FA发展之间相互关系的大规模前瞻性出生队列研究。这些关键因素的识别和他们的独立和联合贡献FA将使我们获得重要的洞察力的生物学机制，环境暴露和遗传易感性影响FA的风险，并将提供必要的信息，以开发更有效的新范式在诊断，预防和管理FA。
Food allergy (FA), a major clinical and public health concern worldwide, is caused by a complex interplay of environmental exposures, genetic variants, gene-environment interactions, and epigenetic alterations. This review summarizes recent advances surrounding these key factors, with a particular focus on the potential role of epigenetics in the development of FA. Epidemiologic studies have reported a number of non-genetic factors that may influence the risk of FA, such as timing of food introduction and feeding pattern, diet/nutrition, exposure to environmental tobacco smoking, prematurity and low birthweight, microbial exposure, and race/ethnicity. Current studies on the genetics of FA are mainly conducted using candidate gene approaches, which have linked more than 10 genes to the genetic susceptibility of FA. Studies on gene-environment interactions of FA are very limited. Epigenetic alteration has been proposed as one of the mechanisms to mediate the influence of early-life environmental exposures and gene-environment interactions on the development of diseases later in life. The role of epigenetics in the regulation of the immune system and the epigenetic effects of some FA-associated environmental exposures are discussed in this review. There is a particular lack of large-scale prospective birth cohort studies that simultaneously assess the inter-relationships of early life exposures, genetic susceptibility, epigenomic alterations and the development of FA. The identification of these key factors and their independent and joint contributions to FA will allow us to gain important insight into the biological mechanisms by which environmental exposures and genetic susceptibility affect the risk of FA, and will provide essential information to develop more effective new paradigms in the diagnosis, prevention and management of FA.
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影响因子：
30.5
作者：
Acosta-Rodriguez, Eva V.;Napolitani, Giorgio;Sallusto, Federica
通讯作者：
Sallusto, Federica
DOI：
10.1016/j.jaci.2010.10.007
发表时间：
2010-12
期刊：
The Journal of allergy and clinical immunology
影响因子：
--
作者：
NIAID-Sponsored Expert Panel;Boyce JA;Assa'ad A;Burks AW;Jones SM;Sampson HA;Wood RA;Plaut M;Cooper SF;Fenton MJ;Arshad SH;Bahna SL;Beck LA;Byrd-Bredbenner C;Camargo CA Jr;Eichenfield L;Furuta GT;Hanifin JM;Jones C;Kraft M;Levy BD;Lieberman P;Luccioli S;McCall KM;Schneider LC;Simon RA;Simons FE;Teach SJ;Yawn BP;Schwaninger JM
通讯作者：
Schwaninger JM
DOI：
10.1016/j.jaci.2011.01.031
发表时间：
2011-03
期刊：
The Journal of allergy and clinical immunology
影响因子：
--
作者：
Brown SJ;Asai Y;Cordell HJ;Campbell LE;Zhao Y;Liao H;Northstone K;Henderson J;Alizadehfar R;Ben-Shoshan M;Morgan K;Roberts G;Masthoff LJ;Pasmans SG;van den Akker PC;Wijmenga C;Hourihane JO;Palmer CN;Lack G;Clarke A;Hull PR;Irvine AD;McLean WH
通讯作者：
McLean WH
影响因子：
14.2
作者：
Brand, Stephanie;Teich, Rene;Renz, Harald
通讯作者：
Renz, Harald
DOI：
10.1164/rccm.200807-1097oc
发表时间：
2009-04-01
影响因子：
24.7
作者：
Baccarelli, Andrea;Wright, Robert O.;Schwartz, Joel
通讯作者：
Schwartz, Joel