The Coppery Age: Copper (Cu)-Involved Nanotheranostics.
The Coppery Age: Copper (Cu)-Involved Nanotheranostics.
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铜时代：涉及铜 (Cu) 的纳米治疗学
DOI：
10.1002/advs.202001549
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发表时间：
2020-11
期刊：
影响因子：
--
通讯作者：
Zhou J
中科院分区：
文献类型：
--
作者：
Dong C;Feng W;Xu W;Yu L;Xiang H;Chen Y;Zhou J
过渡金属铜（Cu）离子作为人体必需的微量元素，是体内的生物活性成分，具有促进血管生成、影响脂质/葡萄糖代谢等特定的生物效应。近年来纳米技术和纳米医学的重大进展促进了独特的铜参与生物材料纳米平台的出现，这些生物材料纳米平台在生物医学中具有有趣的治疗诊断性能，这些平台源于铜物种的生物效应和铜组成的纳米粒子的理化属性。本文基于 Cu 纳米治疗学的最新重大进展，重点讨论了 Cu 组成的功能纳米平台的精心设计和合理构建的原理、进展和前景，用于多种生物医学应用，包括光子纳米医学、催化纳米治疗、抗菌、加速组织 再生和生物成像。还举例说明了用于协同纳米治疗的铜基纳米复合材料的工程，随后揭示了其内在的生物效应和生物安全性，以彻底改变其临床转化。最后，分析了潜在的关键问题、未解决的障碍以及其临床应用的未来前景，并提供了展望。通过进入“铜时代”，这些涉及铜的纳米治疗方式预计将在临床前和临床阶段找到更广泛的生物医学应用，尽管目前的研究和开发仍处于起步阶段。
As an essential trace element in the human body, transitional metal copper (Cu) ions are the bioactive components within the body featuring dedicated biological effects such as promoting angiogenesis and influencing lipid/glucose metabolism. The recent substantial advances of nanotechnology and nanomedicine promote the emerging of distinctive Cu‐involved biomaterial nanoplatforms with intriguing theranostic performances in biomedicine, which are originated from the biological effects of Cu species and the physiochemical attributes of Cu‐composed nanoparticles. Based on the very‐recent significant progresses of Cu‐involved nanotheranostics, this work highlights and discusses the principles, progresses, and prospects on the elaborate design and rational construction of Cu‐composed functional nanoplatforms for a diverse array of biomedical applications, including photonic nanomedicine, catalytic nanotherapeutics, antibacteria, accelerated tissue regeneration, and bioimaging. The engineering of Cu‐based nanocomposites for synergistic nanotherapeutics is also exemplified, followed by revealing their intrinsic biological effects and biosafety for revolutionizing their clinical translation. Finally, the underlying critical concerns, unresolved hurdles, and future prospects on their clinical uses are analyzed and an outlook is provided. By entering the “Copper Age,” these Cu‐involved nanotherapeutic modalities are expected to find more broad biomedical applications in preclinical and clinical phases, despite the current research and developments still being in infancy.
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