In Vivo Tumor Vasculature Targeting of CuS@MSN Based Theranostic Nanomedicine.
In Vivo Tumor Vasculature Targeting of CuS@MSN Based Theranostic Nanomedicine.
复制标题
基于 CuS@MSN 的治疗诊断纳米医学的体内肿瘤脉管系统靶向。
DOI：
10.1021/nn507241v
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发表时间：
2015
期刊：
影响因子：
17.1
通讯作者：
Cai, Weibo
中科院分区：
文献类型：
--
作者：
Chen, Feng;Hong, Hao;Goel, Shreya;Graves, Stephen A.;Orbay, Hakan;Ehlerding, Emily B.;Shi, Sixiang;Theuer, Charles P.;Nickles, Robert J.;Cai, Weibo
关键词：
积极靶向治疗诊断纳米医学可能是未来个性化癌症管理的关键。尽管在过去的十年中已经开发了许多类型的治疗诊断纳米颗粒用于癌症治疗，但在具有高度特异性体内肿瘤靶向能力的生物相容性治疗诊断纳米颗粒的工程化中仍然存在挑战。在这里，我们报告的设计，合成，表面工程，并在体内活性血管靶向的一个新类别的治疗诊断纳米粒子为未来的癌症管理。水溶性光热敏感硫化铜纳米粒子封装在生物相容性介孔二氧化硅壳，然后通过多步表面工程，形成最终的治疗诊断纳米粒子。进行了系统的体外靶向、体内长期毒性研究、光热消融评价、体内血管靶向成像、生物分布和组织学研究，以充分探索所开发的新型治疗诊断纳米颗粒的潜力。
Actively targeted theranostic nanomedicine may be the key for future personalized cancer management. Although numerous types of theranostic nanoparticles have been developed in the past decade for cancer treatment, challenges still exist in the engineering of biocompatible theranostic nanoparticles with highly specific in vivo tumor targeting capabilities. Here, we report the design, synthesis, surface engineering, and in vivo active vasculature targeting of a new category of theranostic nanoparticle for future cancer management. Water-soluble photothermally sensitive copper sulfide nanoparticles were encapsulated in biocompatible mesoporous silica shells, followed by multistep surface engineering to form the final theranostic nanoparticles. Systematic in vitro targeting, an in vivo long-term toxicity study, photothermal ablation evaluation, in vivo vasculature targeted imaging, biodistribution and histology studies were performed to fully explore the potential of as-developed new theranostic nanoparticles.
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影响因子：
14
作者：
Guo, Jintang;Hong, Hao;Chen, Guojun;Shi, Sixiang;Zheng, Qifeng;Zhang, Yin;Theuer, Charles P.;Barnhart, Todd E.;Cai, Weibo;Gong, Shaoqin
通讯作者：
Gong, Shaoqin
影响因子：
17.1
作者：
Hong H;Yang K;Zhang Y;Engle JW;Feng L;Yang Y;Nayak TR;Goel S;Bean J;Theuer CP;Barnhart TE;Liu Z;Cai W
通讯作者：
Cai W
影响因子：
12.4
作者：
Muthu MS;Leong DT;Mei L;Feng SS
通讯作者：
Feng SS
影响因子：
4.6
作者：
Chen F;Hong H;Shi S;Goel S;Valdovinos HF;Hernandez R;Theuer CP;Barnhart TE;Cai W
通讯作者：
Cai W
影响因子：
17.1
作者：
Chen F;Hong H;Zhang Y;Valdovinos HF;Shi S;Kwon GS;Theuer CP;Barnhart TE;Cai W
通讯作者：
Cai W