Cocaine-specific antibodies blunt the subjective effects of smoked cocaine in humans.
Cocaine-specific antibodies blunt the subjective effects of smoked cocaine in humans.
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DOI：
10.1016/j.biopsych.2009.08.031
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发表时间：
2010-01-01
影响因子：
10.6
通讯作者：
Foltin, Richard W.
中科院分区：
文献类型：
--
作者：
Haney, Margaret;Gunderson, Erik W.;Jiang, Huiping;Collins, Eric D.;Foltin, Richard W.
可卡因依赖患者的复发率很高，需要新的治疗方法。临床数据表明，可卡因疫苗（TA-CD：Celtic Pharmaceutical）可产生选择性抗可卡因抗体，但这些抗体对可卡因直接作用的影响尚不清楚。这项人体实验室研究的目的是测量抗体滴度与吸食可卡因对中毒、渴望和心血管影响评级的影响之间的关系。 10 名未寻求药物治疗的可卡因依赖男性在 13 周内每周住院 2 个晚上，在接种疫苗之前和之后每周测定可卡因（0、25、50 毫克）的作用。在第 1、3、5 和 9 周注射两剂 TA-CD（82 µg，n=4；360 µg，n=6）。峰值血浆抗体水平变化很大，可显着预测可卡因的作用。抗体产生量处于上半部分的个体的良好药效和可卡因质量评级立即（吸食可卡因后 4 分钟内）大幅下降（55-81%），而处于下半部分的个体仅表现出不显着的减弱（6-26%）。参与者在门诊期间自我报告的可卡因使用量随着抗体滴度的变化而趋于下降（p < 0.12）。相比之下，较高的抗体水平预示着可卡因诱发的心动过速会显着增加。 TA-CD 疫苗大大降低了吸食可卡因对产生足够抗体的人的中毒作用。这些数据支持进一步测试可卡因免疫疗法作为可卡因依赖的治疗方法。
Rates of relapse among cocaine-dependent patients are high, and new treatment approaches are needed. Clinical data demonstrate that a cocaine vaccine (TA-CD: Celtic Pharmaceutical) produces selective anti-cocaine antibodies, yet the impact of these antibodies on cocaine’s direct effects is unknown. The objective of this human laboratory study was to measure the relationship between antibody titers and the effects of smoked cocaine on ratings of intoxication, craving and cardiovascular effects. Ten cocaine-dependent men not seeking drug treatment spent 2 nights per week for 13 weeks inpatient where the effects of cocaine (0, 25, 50 mg) were determined prior to vaccination and at weekly intervals thereafter. Two doses of TA-CD (82 µg, n=4; 360 µg, n=6) were administered at weeks 1, 3, 5 and 9. Peak plasma antibody levels, which were highly variable, significantly predicted cocaine’s effects. Those individuals in the upper half of antibody production had an immediate (within 4 minutes of cocaine smoking) and robust (55–81%) reduction in ratings of Good Drug Effect and Cocaine Quality, while those in the lower half showed only a nonsignificant attenuation (6–26%). Self-reported cocaine use while participants were outpatient tended to decrease as a function of antibody titer (p < 0.12). By contrast, higher antibody levels predicted significantly greater cocaine-induced tachycardia. The TA-CD vaccine substantially decreased smoked cocaine’s intoxicating effects in those generating sufficient antibody. These data support further testing of cocaine immunotherapy as a treatment for cocaine dependence.
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影响因子：
4.2
作者：
FOLTIN, RW;FISCHMAN, MW;PEARLSON, GD
通讯作者：
PEARLSON, GD
影响因子：
3.4
作者：
Kantak, KN;Collins, SL;Fox, BS
通讯作者：
Fox, BS
影响因子：
2.7
作者：
BALSTER, RL;SCHUSTER, CR
通讯作者：
SCHUSTER, CR
影响因子：
2.3
作者：
Johnson, MW;Ettinger, RH
通讯作者：
Ettinger, RH
影响因子：
7.3
作者：
Paula, S;Tabet, MR;Ball, WJ
通讯作者：
Ball, WJ