Sucrose induces fatty liver and pancreatic inflammation in male breeder rats independent of excess energy intake.
Sucrose induces fatty liver and pancreatic inflammation in male breeder rats independent of excess energy intake.
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DOI：
10.1016/j.metabol.2011.01.008
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发表时间：
2011-09
影响因子：
9.8
通讯作者：
Johnson, Richard J.
中科院分区：
文献类型：
--
作者：
Roncal-Jimenez, Carlos A.;Lanaspa, Miguel A.;Rivard, Christopher J.;Nakagawa, Takahiko;Gabriela Sanchez-Lozada, L.;Jalal, Diana;Andres-Hernando, Ana;Tanabe, Katsuyuki;Madero, Magdalena;Li, Nanxing;Cicerchi, Christina;Mc Fann, Kim;Sautin, Yuri Y.;Johnson, Richard J.
果糖在大鼠中诱导代谢综合征，但研究因使用非生理性的高浓度果糖、仅使用纯果糖以及不控制能量摄入而受到批评。我们测试的假设，40%的蔗糖饮食（含20%的果糖）可能会导致代谢综合征的功能，在雄性繁殖大鼠独立于过量的能量摄入。将雄性Sprague-Dawley繁殖大鼠成对喂食40%蔗糖或等热量淀粉饮食4个月，并评估代谢综合征和糖尿病。在暴露于尿酸的大鼠胰岛素瘤细胞（RIN-m5 F）中进行体外研究，并评估炎症标志物。喂食40%蔗糖饮食的大鼠出现代谢综合征的加速特征，果糖依赖性转运蛋白Glut 5和果糖激酶上调。还发生了脂肪肝和低度胰腺炎症。尿酸被发现刺激炎症介质和氧化应激在体外胰岛细胞。在一部分美国人摄入的浓度下，蔗糖可以加速雄性饲养大鼠的代谢综合征、脂肪肝和2型糖尿病，而且这种影响与过量的能量摄入无关。
Fructose induces metabolic syndrome in rats but studies have been criticized for using high concentrations of fructose that are not physiologic, for using only pure fructose, and for not controlling for energy intake. We tested the hypothesis that a 40% sucrose diet (containing 20% fructose) might induce features of metabolic syndrome in male breeder rats independent of excess energy intake. Male Sprague-Dawley breeder rats were pair fed 40% sucrose or isocaloric starch diet for 4 months and evaluated for metabolic syndrome and diabetes. In vitro studies were performed in rat insulinoma cells (RIN-m5F) exposed to uric acid and markers of inflammation were assessed. Rats fed a 40% sucrose diet developed accelerated features of metabolic syndrome with upregulation of fructose-dependent transporter Glut 5 and fructokinase. Fatty liver and low grade pancreatic inflammation also occurred. Uric acid was found to stimulate inflammatory mediators and oxidative stress in islet cells in vitro. Sucrose, at concentrations ingested by a subset of Americans, can accelerate metabolic syndrome, fatty liver and type 2 diabetes in male breeder rats, and the effects are independent of excess energy intake.
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影响因子：
64.8
作者：
Enomoto, A;Kimura, H;Endou, H
通讯作者：
Endou, H
影响因子：
2.7
作者：
Farah, Vera;Elased, Khalid M.;Morris, Mariana
通讯作者：
Morris, Mariana
DOI：
10.1152/ajpregu.00680.2007
发表时间：
2008-03-01
影响因子：
2.8
作者：
Brown, Clive M.;Dulloo, Abdul G.;Montani, Jean-Pierre
通讯作者：
Montani, Jean-Pierre
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作者：
Corry, Dalila B.;Eslami, Pirooz;Tuck, Michael L.
通讯作者：
Tuck, Michael L.
影响因子：
13.6
作者：
Cirillo, Pietro;Gersch, Michael S.;Sautin, Yuri Y.
通讯作者：
Sautin, Yuri Y.