Seroprevalence Study of Conserved Enterotoxigenic Escherichia coli Antigens in Globally Diverse Populations.
Seroprevalence Study of Conserved Enterotoxigenic Escherichia coli Antigens in Globally Diverse Populations.
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保守产肠毒素大肠杆菌抗原在全球不同人群中的血清阳性率研究。
DOI：
10.3390/microorganisms11092221
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发表时间：
2023-08-31
期刊：
影响因子：
4.5
通讯作者：
Fleckenstein JM
中科院分区：
文献类型：
--
作者：
Kuhlmann FM;Grigura V;Vickers TJ;Prouty MG;Iannotti LL;Dulience SJL;Fleckenstein JM
产肠毒素大肠杆菌（ETEC）是低收入和中等收入国家（LMIC）幼儿和这些地区旅行者感染性腹泻的常见原因。尽管它们对与儿童和旅行者腹泻相关的发病率和死亡率有显著贡献，但没有获得许可的疫苗。目前的疫苗策略可能受益于包含额外的保守抗原，这可能有助于更广泛的覆盖范围和增强的功效，因为它们在促进肠道定植和有效的肠毒素递送中起着关键作用。EatA和EtpA在不同的ETEC人群中广泛保守，但其免疫原性仅在受控的人类感染模型和孟加拉国的儿童人群中进行了研究。在此，我们比较了流行地区人群（包括海地儿童和居住在埃及、喀麦隆和秘鲁的受试者）与散发ETEC感染的美国儿童和成人对EatA、EtpA和不耐热毒素的血清学应答。我们观察到升高的IgG和伊加的反应，从流行地区的每个抗原研究的个人。在一组海地儿童中，我们观察到暴露于每种特征抗原后免疫应答增加。这些结果反映了ETEC感染在多个流行地区的广泛分布，并支持进一步评价EatA和EtpA作为候选ETEC疫苗抗原。
Enterotoxigenic Escherichia coli (ETEC) are common causes of infectious diarrhea among young children of low-and middle-income countries (LMICs) and travelers to these regions. Despite their significant contributions to the morbidity and mortality associated with childhood and traveler’s diarrhea, no licensed vaccines are available. Current vaccine strategies may benefit from the inclusion of additional conserved antigens, which may contribute to broader coverage and enhanced efficacy, given their key roles in facilitating intestinal colonization and effective enterotoxin delivery. EatA and EtpA are widely conserved in diverse populations of ETEC, but their immunogenicity has only been studied in controlled human infection models and a population of children in Bangladesh. Here, we compared serologic responses to EatA, EtpA and heat-labile toxin in populations from endemic regions including Haitian children and subjects residing in Egypt, Cameroon, and Peru to US children and adults where ETEC infections are sporadic. We observed elevated IgG and IgA responses in individuals from endemic regions to each of the antigens studied. In a cohort of Haitian children, we observed increased immune responses following exposure to each of the profiled antigens. These findings reflect the wide distribution of ETEC infections across multiple endemic regions and support further evaluation of EatA and EtpA as candidate ETEC vaccine antigens.
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影响因子：
5.2
作者：
Chan, YuYen;Martin, Diana;Mace, Kimberly E.;Jean, Samuel E.;Stresman, Gillian;Drakeley, Chris;Chang, Michelle A.;Lemoine, Jean F.;Udhayakumar, Venkatachalam;Lammie, Patrick J.;Priest, Jeffrey W.;Rogier, Eric William
通讯作者：
Rogier, Eric William
影响因子：
3.3
作者：
Charles, Macarthur;Delva, Glavdia G.;Pape, Jean W.
通讯作者：
Pape, Jean W.
DOI：
10.3389/fitd.2021.709907
发表时间：
2021-01-01
期刊：
Frontiers in tropical diseases
影响因子：
--
作者：
Fleckenstein, James M
通讯作者：
Fleckenstein, James M
影响因子：
3.4
作者：
Dorsey, F. Chuck;Fischer, Julia F.;Fleckenstein, James M.
通讯作者：
Fleckenstein, James M.
影响因子：
3.8
作者：
Alam, Mohammad Murshid;Aktar, Amena;Qadri, Firdausi
通讯作者：
Qadri, Firdausi