A Case of Cellular Fibrous Histiocytoma on the Right Elbow with Repeated Relapse within a Short Period.
A Case of Cellular Fibrous Histiocytoma on the Right Elbow with Repeated Relapse within a Short Period.
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DOI：
10.1159/000371790
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发表时间：
2015-01
影响因子：
0.9
通讯作者：
Akasaka T
中科院分区：
文献类型：
--
作者：
Tsunoda K;Oikawa H;Maeda F;Takahashi K;Akasaka T
细胞性纤维组织细胞瘤是纤维组织细胞瘤的一种变种，是一种病变，表现为细胞增多，呈束状生长，并经常延伸到皮下组织。我们在此描述一位36岁女性的细胞纤维组织细胞瘤反复复发的病例，最初在她的右肘有一个2厘米长的皮肤肿瘤。病理组织学上，第一例切除的标本可见排列不规则的胶原纤维和散在的增生肥大的梭形纤维组织细胞。但复发后切除的标本检查发现，细胞密度增加，梭形细胞呈单形增殖，呈束状和条状生长，延伸至皮下组织，Ki-67阳性表达增加。由于肿瘤在短时间内反复复发，我们进行了肿瘤的大范围切除，切缘3厘米。目前，术后48个月未见局部复发或转移，但仍需持续严格随访。
Cellular fibrous histiocytoma, a variant of fibrous histiocytoma, is a designation used for lesions showing increased cellularity with a fascicular growth pattern and frequent extension into the subcutis. Here we describe a case of cellular fibrous histiocytoma showing repeated recurrence in a 36-year-old woman who initially presented with a 2-cm cutaneous tumor on her right elbow. Histopathologically, the first resected specimen demonstrated irregularly arranged collagen fibers mixed with scattered proliferating plump to spindle-shaped fibrohistiocytes. However, examination of the resected specimens obtained after recurrence showed that the cellularity had increased, the spindle-shaped cells showing monomorphic proliferation with a fascicular and storiform growth pattern extending into the subcutis, as well as an increase of Ki-67 positivity. Since the lesion showed repeated relapse within a short period, we performed wide-field resection of the tumor with a 3-cm margin. Currently, 48 months after surgery, there has been no local recurrence or metastasis, but continuous strict follow-up will be necessary.
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