Cancellous bone-like tissue replacement from calcinosis in patients with systemic sclerosis with multiple external root resorption.
Cancellous bone-like tissue replacement from calcinosis in patients with systemic sclerosis with multiple external root resorption.
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患有多发性外根吸收的系统性硬化症患者钙质沉着的松质骨样组织替代物。
DOI：
10.1016/j.bonr.2021.101165
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发表时间：
2022-06
期刊：
影响因子：
2.5
通讯作者：
Mizuno N
中科院分区：
文献类型：
--
作者：
Memida T;Matsuda S;Nakamoto T;Ouhara K;Kajiya M;Hirata S;Sugiyama E;Kakimoto N;Mizuno N
钙质沉着症常见于系统性硬化症（SSc）患者。钙质沉着症的基本治疗方法尚未确立。在随访期间，皮下表面的钙质沉着通常自发地被提取或保持被纤维组织限制。我们以前发现了SSc患者的一个新症状，多发性外根吸收（MERR），这些患者的鼻棘有钙化。在此，我们首次报道了MERR患者鼻棘的钙质沉着可以被松质骨样组织替代。患者1和2分别为患有MERR的62岁日本女性和45岁日本女性，其先前曾接受过SSc治疗（患者1：局限型，抗着丝粒抗体阳性;患者2：弥漫型，抗Scl 70和抗SS-A抗体阳性）。患者3是一例57岁MERR女性，既往接受过SSc（弥漫型，抗Scl-70抗体阳性）治疗，并接受过地舒单抗注射治疗骨质疏松症。患者1和2的鼻棘钙化中的锥形束计算机断层扫描（CBCT）和CT图像被松质骨样组织替代，但患者3未被替代。进行血清实验室检查以评估全身性骨病。除了患者1中的1，25-二羟维生素D水平略高外，所有三名患者的临床数据均在参考范围内。颌面部钙质沉着的SSc患者需要使用CBCT或CT仔细检查骨置换。
Calcinosis is frequently observed in patients with systemic sclerosis (SSc). The fundamental treatment of calcinosis has not yet been established. During follow-up, calcinosis in the subcutaneous surface is often spontaneously extracted or remains confined by fibrous tissues. We previously identified a new symptom in SSc patients, multiple external root resorption (MERR), and these patients had calcifications in the nasal spine. Here, we report for the first time that calcinosis at the nasal spine in patients with MERR can be replaced by cancellous bone-like tissue. Patients 1 and 2 were a 62-year-old Japanese female and a 45-year-old Japanese female (respectively) with MERR who had been previously treated for SSc (Patient 1: limited type, positive for anti-centromere antibody; Patient 2: diffuse type, positive for anti-Scl70 and anti-SS-A antibodies). Patient 3 was a 57-year-old female with MERR who had been previously treated for SSc (diffuse type, positive anti-Scl-70 antibody) and underwent denosumab injection for osteoporosis. Cone-beam computed tomography (CBCT) and CT images in the calcifications at the nasal spine in Patient 1 and 2 were replaced with cancellous bone-like tissue, but not in Patient 3. Serum laboratory examination was performed to assess the systemic bone disease. All three patients had normal clinical data within the references, apart from slightly higher 1,25-dihydroxyvitamin D levels in Patient 1. SSc patients with calcinosis in the maxillofacial area need to be examined carefully for bone replacement using CBCT or CT.
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影响因子：
4.1
作者：
Lees-Shepard JB;Goldhamer DJ
通讯作者：
Goldhamer DJ
影响因子：
2
作者：
Adegbite, N. S.;Xu, M.;Kaplan, F. S.;Shore, E. M.;Pignolo, R. J.
通讯作者：
Pignolo, R. J.
DOI：
10.1634/theoncologist.2010-0154
发表时间：
2011
期刊：
The oncologist
影响因子：
--
作者：
Castellano D;Sepulveda JM;García-Escobar I;Rodriguez-Antolín A;Sundlöv A;Cortes-Funes H
通讯作者：
Cortes-Funes H
影响因子：
2.2
作者：
Chindasombatjaroen, Jira;Kakimoto, Naoya;Furukawa, Souhei
通讯作者：
Furukawa, Souhei
影响因子：
6
作者：
Simionescu, Agneta;Sirnionescu, Dan T.;Vyavahare, Narendra R.
通讯作者：
Vyavahare, Narendra R.