Whole-body lifetime occupational lead exposure and risk of Parkinson's disease.
Whole-body lifetime occupational lead exposure and risk of Parkinson's disease.
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DOI：
10.1289/ehp.9102
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发表时间：
2006-12
影响因子：
10.4
通讯作者：
Gorell J
中科院分区：
文献类型：
--
作者：
Coon S;Stark A;Peterson E;Gloi A;Kortsha G;Pounds J;Chettle D;Gorell J
一些流行病学研究表明，帕金森病（PD）和接触重金属之间的关联使用主观暴露测量。我们调查了客观的慢性职业性铅暴露与PD风险之间的关系。我们在一项病例对照研究中招募了121名PD患者和414名年龄、性别、种族、频率匹配的对照。作为慢性铅暴露的指标，我们使用109镉激发的K系列X射线荧光测量胫骨和跟骨铅商店的浓度。作为近期暴露的指标，我们测量了血铅浓度。我们收集了从18岁到入学年龄的参与者的职业数据，并由一名工业卫生学家确定了环境铅暴露的持续时间和强度。我们采用基于生理学的药代动力学模型结合联合收割机这些数据，我们估计全身寿命铅暴露为每个人。Logistic回归分析产生的PD风险的四分位数的终身铅暴露的估计。调整年龄、性别、种族、吸烟史、咖啡和酒精摄入量后，终生铅暴露量最高四分位数的个体患PD的风险比最低四分位数的个体高2倍[比值比= 2.27（95%置信区间，1.13-4.55）; p = 0.021]。第二和第三四分位数的PD相关风险升高，但在α = 0.05水平下无统计学显著性。这些结果提供了一个客观的措施，慢性铅暴露，并证实了我们早期的研究结果，铅的职业暴露是一个危险因素PD。
Several epidemiologic studies have suggested an association between Parkinson’s disease (PD) and exposure to heavy metals using subjective exposure measurements. We investigated the association between objective chronic occupational lead exposure and the risk of PD. We enrolled 121 PD patients and 414 age-, sex-, and race-, frequency-matched controls in a case–control study. As an indicator of chronic Pb exposure, we measured concentrations of tibial and calcaneal bone Pb stores using 109Cadmium excited K-series X-ray fluorescence. As an indicator of recent exposure, we measured blood Pb concentration. We collected occupational data on participants from 18 years of age until the age at enrollment, and an industrial hygienist determined the duration and intensity of environmental Pb exposure. We employed physiologically based pharmacokinetic modeling to combine these data, and we estimated whole-body lifetime Pb exposures for each individual. Logistic regression analysis produced estimates of PD risk by quartile of lifetime Pb exposure. Risk of PD was elevated by > 2-fold [odds ratio = 2.27 (95% confidence interval, 1.13–4.55); p = 0.021] for individuals in the highest quartile for lifetime lead exposure relative to the lowest quartile, adjusting for age, sex, race, smoking history, and coffee and alcohol consumption. The associated risk of PD for the second and third quartiles were elevated but not statistically significant at the α = 0.05 level. These results provide an objective measure of chronic Pb exposure and confirm our earlier findings that occupational exposure to Pb is a risk factor for PD.
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影响因子：
6.9
作者：
ANTHONY, JC;LERESCHE, L;FOLSTEIN, MF
通讯作者：
FOLSTEIN, MF
影响因子：
3.9
作者：
POPENOE, EA;SCHMAELER, MA
通讯作者：
SCHMAELER, MA
DOI：
10.1080/15298669191364956
发表时间：
1991-10-01
期刊：
AMERICAN INDUSTRIAL HYGIENE ASSOCIATION JOURNAL
影响因子：
--
作者：
SHARP, DS;PERKINS, C;RUDOLPH, L
通讯作者：
RUDOLPH, L
DOI：
10.1111/j.1600-0773.1994.tb01077.x
发表时间：
1994-02-01
期刊：
PHARMACOLOGY & TOXICOLOGY
影响因子：
--
作者：
SANDHIR, R;JULKA, D;GILL, KD
通讯作者：
GILL, KD
影响因子：
4.8
作者：
FOLSTEIN, MF;FOLSTEIN, SE;MCHUGH, PR
通讯作者：
MCHUGH, PR