Hall of Fame among Pro-inflammatory Cytokines: Interleukin-6 Gene and Its Transcriptional Regulation Mechanisms.
Hall of Fame among Pro-inflammatory Cytokines: Interleukin-6 Gene and Its Transcriptional Regulation Mechanisms.
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DOI：
10.3389/fimmu.2016.00604
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发表时间：
2016
影响因子：
7.3
通讯作者：
Zheng SG
中科院分区：
文献类型：
--
作者：
Luo Y;Zheng SG
促炎细胞因子是由免疫系统细胞产生并介导多种免疫反应的内源性多肽。它们也是自身免疫系统的效应器。人们普遍认为白细胞介素（IL）-4、IL-6、IL-9、IL-17和肿瘤坏死因子-α是促炎细胞因子；然而，IL-6 成为其中的主角，因为它主要诱导促炎信号传导并调节大量细胞过程。现已确定IL-6与大量具有炎症背景的疾病有关，如慢性病贫血、血管生成急性期反应、骨代谢、软骨代谢以及多种癌症等。尽管相关领域取得了巨大进展，但针对治疗益处的 IL-6 反应的靶向调节仍有待完全了解。因此，可以想象，从基因调控的角度了解IL-6的作用机制，可以更好地有助于确定疾病的发病机制，为临床治疗转化提供更坚实的科学依据。在这篇综述中，我们从基因转录调控的角度总结了与临床靶向治疗相关的候选基因。
Pro-inflammatory cytokines that are generated by immune system cells and mediate many kinds of immune responses are kinds of endogenous polypeptides. They are also the effectors of the autoimmune system. It is generally accepted that interleukin (IL)-4, IL-6, IL-9, IL-17, and tumor necrosis factor-α are pro-inflammatory cytokines; however, IL-6 becomes a protagonist among them since it predominately induces pro-inflammatory signaling and regulates massive cellular processes. It has been ascertained that IL-6 is associated with a large number of diseases with inflammatory background, such as anemia of chronic diseases, angiogenesis acute-phase response, bone metabolism, cartilage metabolism, and multiple cancers. Despite great progress in the relative field, the targeted regulation of IL-6 response for therapeutic benefits remains incompletely to be understood. Therefore, it is conceivable that understanding mechanisms of IL-6 from the perspective of gene regulation can better facilitate to determine the pathogenesis of the disease, providing more solid scientific basis for clinical treatment translation. In this review, we summarize the candidate genes that have been implicated in clinical target therapy from the perspective of gene transcription regulation.
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影响因子：
64.5
作者：
BAEUERLE, PA;BALTIMORE, D
通讯作者：
BALTIMORE, D
影响因子：
11.4
作者：
AKIRA, S;ISSHIKI, H;KISHIMOTO, T
通讯作者：
KISHIMOTO, T
影响因子：
15.9
作者：
Fishman, D;Faulds, G;Woo, P
通讯作者：
Woo, P
DOI：
10.1016/j.jsgi.2005.03.005
发表时间：
2005-07-01
期刊：
JOURNAL OF THE SOCIETY FOR GYNECOLOGIC INVESTIGATION
影响因子：
--
作者：
Bhanoori, M;Babu, KA;Shivaji, S
通讯作者：
Shivaji, S
DOI：
10.1016/s1357-2725(96)00159-8
发表时间：
1997-06-01
影响因子：
4
作者：
Barnes, PJ
通讯作者：
Barnes, PJ