Stromal-to-epithelial transition during postpartum endometrial regeneration.
Stromal-to-epithelial transition during postpartum endometrial regeneration.
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DOI：
10.1371/journal.pone.0044285
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Behringer RR
中科院分区：
文献类型：
--
作者：
Huang CC;Orvis GD;Wang Y;Behringer RR
子宫内膜是子宫的内层，由上皮和基质组织组成，被子宫肌层的两个平滑肌层包围。在女性中，月经周期期间，每个月都有大量子宫内膜脱落和再生。子宫内膜再生也发生在分娩后。调节子宫内膜再生的细胞机制仍然知之甚少。利用小鼠的遗传命运作图，我们发现子宫内膜的上皮区室在发情周期和产后再生期间保持其上皮身份。然而，尽管基质隔室在稳态循环期间保持其身份，但分娩后基质细胞的子集分化成随后维持的上皮。这些发现确定了子宫内膜间质区室中在产后子宫内膜再生期间产生长期上皮组织的潜在祖细胞。
Endometrium is the inner lining of the uterus which is composed of epithelial and stromal tissue compartments enclosed by the two smooth muscle layers of the myometrium. In women, much of the endometrium is shed and regenerated each month during the menstrual cycle. Endometrial regeneration also occurs after parturition. The cellular mechanisms that regulate endometrial regeneration are still poorly understood. Using genetic fate-mapping in the mouse, we found that the epithelial compartment of the endometrium maintains its epithelial identity during the estrous cycle and postpartum regeneration. However, whereas the stromal compartment maintains its identity during homeostatic cycling, after parturition a subset of stromal cells differentiates into epithelium that is subsequently maintained. These findings identify potential progenitor cells within the endometrial stromal compartment that produce long-term epithelial tissue during postpartum endometrial regeneration.
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