Skin T cells maintain their diversity and functionality in the elderly.
Skin T cells maintain their diversity and functionality in the elderly.
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DOI：
10.1038/s42003-020-01551-7
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发表时间：
2021-01-04
影响因子：
5.9
通讯作者：
Watanabe R
中科院分区：
文献类型：
--
作者：
Koguchi-Yoshioka H;Hoffer E;Cheuk S;Matsumura Y;Vo S;Kjellman P;Grema L;Ishitsuka Y;Nakamura Y;Okiyama N;Fujisawa Y;Fujimoto M;Eidsmo L;Clark RA;Watanabe R
最近的研究强调，人类驻留记忆T细胞（TRM）在功能上不同于循环T细胞。因此，可以假设皮肤T细胞的老化与血液循环T细胞不同。我们评估了不同年龄段个体的T细胞密度、多样性和功能，以研究来自两个不同国家的人类皮肤衰老对免疫学的影响。随着年龄的增长，T细胞密度没有下降，表皮CD49a + CD8 TRM的频率在老年人中增加，无论种族如何。T细胞多样性和抗病原体反应在老年人的皮肤中保持，但在血液中下降。我们的研究结果表明，在老年人中，皮肤T细胞保持其密度，多样性和保护性细胞因子的产生，尽管血液中的T细胞多样性和功能降低。皮肤驻留T细胞可能代表了老年人免疫力的长期，高度保护性水库。Koguchi-Yoshioka等人证明，与血液中的T细胞相比，无论参与者的种族或实验程序如何，老年人皮肤中的T细胞的功能活性和多样性都得到了高度维持。他们还发现，在老年参与者中，表皮T细胞的积累与维持细胞因子的产生有关。
Recent studies have highlighted that human resident memory T cells (TRM) are functionally distinct from circulating T cells. Thus, it can be postulated that skin T cells age differently from blood-circulating T cells. We assessed T-cell density, diversity, and function in individuals of various ages to study the immunologic effects of aging on human skin from two different countries. No decline in the density of T cells was noted with advancing age, and the frequency of epidermal CD49a+ CD8 TRM was increased in elderly individuals regardless of ethnicity. T-cell diversity and antipathogen responses were maintained in the skin of elderly individuals but declined in the blood. Our findings demonstrate that in elderly individuals, skin T cells maintain their density, diversity, and protective cytokine production despite the reduced T-cell diversity and function in blood. Skin resident T cells may represent a long-lived, highly protective reservoir of immunity in elderly people. Koguchi-Yoshioka et al. demonstrate that functional activities and diversity of T cells are highly maintained in the skin of elderly people when compared with those in the blood regardless of the ethnicity of the participants or the experimental procedures. They also find the accumulation of epidermal T cells with maintained cytokine production in the elderly participants.
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影响因子：
4.4
作者：
Masopust, D;Vezys, V;Ahmed, R
通讯作者：
Ahmed, R
影响因子：
64.8
作者：
Jiang, Xiaodong;Clark, Rachael A.;Liu, Luzheng;Wagers, Amy J.;Fuhlbrigge, Robert C.;Kupper, Thomas S.
通讯作者：
Kupper, Thomas S.
影响因子：
17.1
作者：
Clark RA;Watanabe R;Teague JE;Schlapbach C;Tawa MC;Adams N;Dorosario AA;Chaney KS;Cutler CS;Leboeuf NR;Carter JB;Fisher DC;Kupper TS
通讯作者：
Kupper TS
影响因子：
3.7
作者：
Bowen AC;Mahé A;Hay RJ;Andrews RM;Steer AC;Tong SY;Carapetis JR
通讯作者：
Carapetis JR
影响因子：
16.6
作者：
Collins N;Jiang X;Zaid A;Macleod BL;Li J;Park CO;Haque A;Bedoui S;Heath WR;Mueller SN;Kupper TS;Gebhardt T;Carbone FR
通讯作者：
Carbone FR