Association between Parkinson's disease and risk of prostate cancer in different populations: An updated meta-analysis.
Association between Parkinson's disease and risk of prostate cancer in different populations: An updated meta-analysis.
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DOI：
10.1038/s41598-017-13834-x
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发表时间：
2017-10-18
影响因子：
4.6
通讯作者：
Hu Z
中科院分区：
文献类型：
--
作者：
Chen C;Zheng H;Hu Z
最近，越来越多的证据表明帕金森病（PD）和癌症之间存在显著关联。然而，关于PD和前列腺癌之间的关联仍然存在争议。使用在线数据库PubMed、Web of Science和Embase对截至2017年1月1日的相关已发表研究进行了全面的文献检索。使用随机效应模型的逆方差法计算合并风险比（RR）及其95%置信区间（CI）。本研究纳入了15项研究，包括346，153例PD患者。本研究结果显示，在西方人群中，PD与前列腺癌风险降低显著相关（RR：0.83，95% CI：0.72-0.95，P < 0.01），而在亚洲人群中，PD与前列腺癌风险增加显著相关（RR：1.80，95% CI：1.52-2.13，P < 0.001）。在亚组分析中，无论研究设计或研究质量如何，西方人群中PD患者的前列腺癌风险降低是一致的。总之，在西方人群中，PD与前列腺癌风险降低显著相关。亚洲人群中这些疾病之间的关系需要通过未来的研究来证实。
Recently, growing evidence has revealed a significant association between Parkinson’s disease (PD) and cancer. However, controversy still exists concerning the association between PD and prostate cancer. A comprehensive article search for relevant published studies was performed using the online databases PubMed, Web of Science and Embase up to January 1, 2017. The pooled risk ratios (RRs) and their 95% confidence intervals (CIs) were calculated using the method of inverse variance with a random-effects model. Fifteen studies comprising 346,153 PD patients were included in this study. The results of the present study showed that PD was significantly associated with a decreased risk of prostate cancer in the Western population (RR: 0.83, 95% CI: 0.72–0.95, P < 0.01), while an increased risk of prostate cancer was shown in the Asian population (RR: 1.80, 95% CI: 1.52–2.13, P < 0.001). In the subgroup analysis, the reduced risk of prostate cancer in PD patients from Western populations was consistent regardless of study design or study quality. In conclusion, PD was significantly associated with a reduced risk of prostate cancer in the Western population. The relationship between those conditions in the Asian population needs to be confirmed by future studies.
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