Disruption of brain connectivity in acute stroke patients with early impairment in consciousness.
Disruption of brain connectivity in acute stroke patients with early impairment in consciousness.
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DOI：
10.3389/fpsyg.2013.00956
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发表时间：
2014
影响因子：
3.8
通讯作者：
Biswal BB
中科院分区：
文献类型：
--
作者：
Tsai YH;Yuan R;Huang YC;Yeh MY;Lin CP;Biswal BB
意识障碍在急性脑卒中患者中很常见，且与卒中后的临床结果相关。其潜在机制尚未完全明确，对于意识障碍的急性脑卒中患者的大脑活动和连接性变化知之甚少。在本研究中，我们研究了意识障碍的脑卒中患者的局部大脑活动和大脑网络的变化，以及每个时间序列的自发低频波动幅度（ALFF）。测量了每个体素的局部一致性（ReHo），并随后进行了静息态网络分析。本研究结果表明，与正常受试者相比，意识障碍的脑卒中患者的楔前叶和后扣带回皮质区域的ALFF强度、ReHo以及默认模式网络（DMN）连接强度显著降低。此外，DMN的强度与发病时间和扫描时间之间的格拉斯哥昏迷评分（GCS）差异高度相关。本研究结果表明，静息态功能磁共振成像（fMRI）是评估早期意识障碍的急性脑卒中患者的一种可行工具。这些表现出变化的大脑活动和网络的详细机制及其影响将需要进一步研究。
Impairment in consciousness is common in acute stroke patients and is correlated with the clinical outcome after stroke. The underlying mechanism is not completely understood, with little known about brain activity and connectivity changes in acute stroke patients having impaired consciousness. In this study, we investigated changes in regional brain activity and brain networks of consciousness impaired stroke patients, as well as the amplitude of spontaneous low frequency fluctuation (ALFF) of each time series. Regional homogeneity (ReHo) of each voxel was measured, and resting state network analysis was consequently conducted. Results from this study demonstrate that, compared to normal subjects, the intensities of ALFF and ReHo, as well as the strength of the default mode network (DMN) connectivity, were significantly decreased in the precuneus and posterior cingulate cortex regions among stroke patients with impaired consciousness. Furthermore, the strength of the DMN was highly correlated with differences in the Glasgow Coma Scale (GCS) scores between the onset time and the scanning time. Results from this study suggest that the resting state fMRI is a feasible tool for the evaluation of acute stroke patients with an early impairment of consciousness. The detailed mechanisms, implications of these brain activities and networks exhibiting changes will require further investigation.
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影响因子：
3.7
作者：
Di, Xin;Kannurpatti, Sridhar S.;Biswal, Bharat B.
通讯作者：
Biswal, Bharat B.
DOI：
10.1098/rstb.2005.1634
发表时间：
2005-05-29
影响因子：
6.3
作者：
Beckmann, CF;DeLuca, M;Smith, SM
通讯作者：
Smith, SM
DOI：
10.1073/pnas.0308627101
发表时间：
2004-03-30
影响因子：
11.1
作者：
Greicius, MD;Srivastava, G;Menon, V
通讯作者：
Menon, V
影响因子：
10.6
作者：
Greicius, Michael D.;Flores, Benjamin H.;Schatzberg, Alan F.
通讯作者：
Schatzberg, Alan F.
影响因子：
64.8
作者：
Maquet, P;Peters, JM;Franck, G
通讯作者：
Franck, G