HEALTHY study rationale, design and methods: moderating risk of type 2 diabetes in multi-ethnic middle school students.
HEALTHY study rationale, design and methods: moderating risk of type 2 diabetes in multi-ethnic middle school students.
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DOI：
10.1038/ijo.2009.112
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发表时间：
2009-08
影响因子：
4.9
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中科院分区：
文献类型：
--
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健康一级预防试验的设计和实施是为了应对越来越多的儿童和青少年被诊断患有2型糖尿病。目的是降低2型糖尿病的危险因素。测量的可改变的风险因素是肥胖和血糖失调的指标：体重指数≥第85百分位数，空腹血糖≥5.55 mmol l-1（100 mg/100 ml）和空腹胰岛素≥180 pmol l-1（30 μU ml-1）。一系列试点研究确定了执行数据收集程序的可行性，并测试了由四个综合组成部分组成的干预措施的发展：（1）整个学校食品环境中食品和饮料供应的数量和营养质量的变化;（2）体育课教案和配套设备，以增加参与和花费在中到这些活动包括：（1）积极的体育活动;（2）简单的课堂活动和家庭外展工具，以增加知识，提高决策技能，支持和加强青年实现目标;（3）传播和社会营销战略，通过信息、图像、事件和活动加强和促进变革。专家研究人员为学校教职员工提供培训、援助、材料和指导，以实施干预措施。一组学生在六年级入学，并跟踪到八年级结束。他们在基线和研究结束时参加了健康筛查数据收集，包括测量身高，体重，血压，腰围和空腹抽血。在七年级结束时还收集了身高和体重。该研究在42所中学进行，全国7个地点各6所，其中21所学校随机接受干预，21所作为对照（仅数据收集活动）。样本量和把握度计算、随机化、干预和主要分析均以中学为单位。
The HEALTHY primary prevention trial was designed and implemented in response to the growing numbers of children and adolescents being diagnosed with type 2 diabetes. The objective was to moderate risk factors for type 2 diabetes. Modifiable risk factors measured were indicators of adiposity and glycemic dysregulation: body mass index ≥85th percentile, fasting glucose ≥5.55 mmol l-1 (100 mg per 100 ml) and fasting insulin ≥180 pmol l-1 (30 μU ml-1). A series of pilot studies established the feasibility of performing data collection procedures and tested the development of an intervention consisting of four integrated components: (1) changes in the quantity and nutritional quality of food and beverage offerings throughout the total school food environment; (2) physical education class lesson plans and accompanying equipment to increase both participation and number of minutes spent in moderate-to-vigorous physical activity; (3) brief classroom activities and family outreach vehicles to increase knowledge, enhance decision-making skills and support and reinforce youth in accomplishing goals; and (4) communications and social marketing strategies to enhance and promote changes through messages, images, events and activities. Expert study staff provided training, assistance, materials and guidance for school faculty and staff to implement the intervention components. A cohort of students were enrolled in sixth grade and followed to end of eighth grade. They attended a health screening data collection at baseline and end of study that involved measurement of height, weight, blood pressure, waist circumference and a fasting blood draw. Height and weight were also collected at the end of the seventh grade. The study was conducted in 42 middle schools, six at each of seven locations across the country, with 21 schools randomized to receive the intervention and 21 to act as controls (data collection activities only). Middle school was the unit of sample size and power computation, randomization, intervention and primary analysis.
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影响因子：
4.9
作者：
Drews, K. L.;Harrell, J. S.;Thompson, D.;Mazzuto, S. L.;Ford, E. G.;Carter, M.;Ford, D. A.;Yin, Z.;Jessup, A. N.;Roullet, J-B
通讯作者：
Roullet, J-B
影响因子：
3
作者：
Feeny, D;Furlong, W;Boyle, M
通讯作者：
Boyle, M
影响因子：
16.2
作者：
Ford, Earl S.;Li, Chaoyang;Cook, Stephen
通讯作者：
Cook, Stephen
影响因子：
7.7
作者：
Goran, MI;Gower, BA
通讯作者：
Gower, BA
影响因子：
4.9
作者：
Gillis, B.;Mobley, C.;McCormick, S.
通讯作者：
McCormick, S.