Emotional fronto-cingulate cortex activation and brain derived neurotrophic factor polymorphism in premenstrual dysphoric disorder.
Emotional fronto-cingulate cortex activation and brain derived neurotrophic factor polymorphism in premenstrual dysphoric disorder.
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DOI：
10.1002/hbm.22486
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发表时间：
2014-09
影响因子：
4.8
通讯作者：
Sundstrom-Poromaa, Inger
中科院分区：
文献类型：
--
作者：
Comasco, Erika;Hahn, Andreas;Ganger, Sebastian;Gingnell, Malin;Bannbers, Elin;Oreland, Lars;Wikstrom, Johan;Epperson, C. Neill;Lanzenberger, Rupert;Sundstrom-Poromaa, Inger
经前焦虑障碍（PMDD）是一种典型的性别特异性疾病，其中症状的发作和抵消需要特定的激素环境，并且存在中度遗传性。本研究调查了PMDD和健康对照的大脑情绪处理，以及PMDD的两个候选基因5-羟色胺转运体（5-HTT）和脑源性神经营养因子（BDNF）的功能多态性。在31例PMDD患者和31例健康对照者中进行5-HTT连锁多态性区域（5-HTTLPR）和BDNF Val 66 Met多态性基因分型。16名患者和15名对照参与了两次功能性磁共振成像-执行情绪处理任务;一次在卵泡中期，一次在黄体晚期，这与情绪症状的最大严重程度相对应。基因型与PMDD无直接关系。在全脑分析中发现了组的主要效应，患者的膝前扣带回和腹内侧前额叶皮层的激活较低，与月经周期阶段无关。在额扣带簇中的事后功能ROI分析显示，5-HTTLPR基因型没有影响，但BDNF Val 66 Met的基因型-组-时相相互作用效应。与携带Met等位基因的对照组相比，携带Met等位基因的PMDD女性在黄体期的额扣带皮层激活较低。结果提供了PMDD患者中情绪诱导的额扣带皮层激活受损的暗示性证据。虽然受小样本的限制，但BDNF Val 66 Met对PMDD的潜在影响与临床前研究结果一致。《脑地图》35：4450-4458，2014年。© 2014作者。人脑绘图由Wiley Periodicals，Inc.出版
Premenstrual dysphoric disorder (PMDD) is the prototypical sex‐specific disorder in which symptom onset and offset require a particular hormonal milieu and for which there is moderate heritability. The present study investigated brain emotion processing in PMDD and healthy controls, as well as functional polymorphisms in two candidate genes for PMDD, the serotonin transporter (5‐HTT) and brain derived neurotrophic factor (BDNF). The 5‐HTT linked polymorphic region (5‐HTTLPR) and BDNF Val66Met polymorphisms were genotyped in 31 patients with PMDD and 31 healthy controls. A subset of 16 patients and 15 controls participated in two functional magnetic resonance imaging‐sessions performing an emotion processing task; once in the mid‐follicular, and once in the late luteal phase which corresponds with maximum severity of mood symptoms. Genotypes were not directly associated with PMDD. A main effect of group was found in the whole brain analysis, with patients having lower activation of the pre‐genual anterior cingulate and ventro‐medial prefrontal cortex, independent of menstrual cycle phase. Post‐hoc functional ROI analyses in the fronto‐cingulate cluster showed no effect of 5‐HTTLPR genotype but a genotype‐by‐group‐by‐phase interaction effect of BDNF Val66Met. Women with PMDD who were carriers of the Met‐allele had lower fronto‐cingulate cortex activation in the luteal phase compared to Met‐allele carrying controls. The results provide suggestive evidence of impaired emotion‐induced fronto‐cingulate cortex activation in PMDD patients. Although limited by a small sample, the potential influence of BDNF Val66Met in PMDD is in line with preclinical findings. Hum Brain Mapp 35:4450–4458, 2014. © 2014 The Authors. Human Brain Mapping Published by Wiley Periodicals, Inc.
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影响因子：
10.6
作者：
Bath, Kevin G.;Chuang, Jocelyn;Spencer-Segal, Joanna L.;Amso, Dima;Altemus, Margaret;McEwen, Bruce S.;Lee, Francis S.
通讯作者：
Lee, Francis S.
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Kalisch, Raffael
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Epperson, CN;Haga, K;Krystal, JH
通讯作者：
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作者：
Hariri, AR;Mattay, VS;Weinberger, DR
通讯作者：
Weinberger, DR
影响因子：
25
作者：
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通讯作者：
Lu, Bai