Pretrial predictors of conflict response efficacy in the human prefrontal cortex.

Pretrial predictors of conflict response efficacy in the human prefrontal cortex.
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DOI:
10.1016/j.isci.2023.108047
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发表时间:
2023-11-17
期刊:
影响因子:
5.8
通讯作者:
Sheth, Sameer A.
Sheth, Sameer A.
中科院分区:
综合性期刊2区
文献类型:
--
作者:
Herman, Alexander B.;Smith, Elliot H.;Schevon, Catherine A.;Yates, Mark J.;Mckhann, Guy M.;Botvinick, Matthew;Hayden, Benjamin Y.;Sheth, Sameer A.

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执行运动动作的能力部分取决于大脑的初始状态。我们假设,初始状态依赖是一个更普遍的原则,适用于认知控制。为了验证这一想法,我们研究了人类单个单位记录从背外侧前额叶(dlPFC)皮层和背侧前扣带皮层(dACC)在一个任务,交织运动和知觉冲突试验,多频干扰任务(MSIT)。在这两个大脑区域中,试验前放电率的变化预测了冲突试验的后续反应时间(RT)。在dlPFC中,集合放电率模式表明存在特定域的初始状态,而在dACC中,放电模式更符合域一般的初始状态。部署的共享和独立的因素,我们观察到的冲突解决可能会允许灵活和快速的反应介导的认知初始状态。这些结果也支持假设,把dACC层次早于dlPFC在主动控制。dlPFC和dACC人类神经元“初始状态”放电模式预测反应时间dlPFC中的一般域初始状态在dACC中的冲突反应中崩溃在dlPFC中,初始状态包括特定域组件dlPFC特定域组件正交定向生物科学;神经科学;系统神经科学;认知神经科学
The ability to perform motor actions depends, in part, on the brain’s initial state. We hypothesized that initial state dependence is a more general principle and applies to cognitive control. To test this idea, we examined human single units recorded from the dorsolateral prefrontal (dlPFC) cortex and dorsal anterior cingulate cortex (dACC) during a task that interleaves motor and perceptual conflict trials, the multisource interference task (MSIT). In both brain regions, variability in pre-trial firing rates predicted subsequent reaction time (RT) on conflict trials. In dlPFC, ensemble firing rate patterns suggested the existence of domain-specific initial states, while in dACC, firing patterns were more consistent with a domain-general initial state. The deployment of shared and independent factors that we observe for conflict resolution may allow for flexible and fast responses mediated by cognitive initial states. These results also support hypotheses that place dACC hierarchically earlier than dlPFC in proactive control. dlPFC and dACC human neuron “initial state” firing patterns predicted response times A domain-general initial state collapsed across conflict responses in dACC In dlPFC, the initial state comprised domain-specific components The dlPFC domain-specific components were oriented orthogonally Biological sciences; Neuroscience; Systems neuroscience; Cognitive neuroscience
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