Orbitofrontal cortex uses distinct codes for different choice attributes in decisions motivated by curiosity.

Orbitofrontal cortex uses distinct codes for different choice attributes in decisions motivated by curiosity.
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眶额皮层在好奇心驱使下的决策中使用不同的代码来表示不同的选择属性。

DOI:
10.1016/j.neuron.2014.12.050
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发表时间:
2015-02-04
期刊:
影响因子:
16.2
通讯作者:
Bromberg-Martin, Ethan S.
Bromberg-Martin, Ethan S.
中科院分区:
医学1区
文献类型:
--
作者:
Blanchard, Tommy C.;Hayden, Benjamin Y.;Bromberg-Martin, Ethan S.

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决策者很好奇,因此重视有关未来事件的预先信息。我们利用这一事实来测试眶额皮层 (OFC) 13 区价值表征的竞争理论。在一项新任务中,我们发现猴子可靠地牺牲了主要奖励(水)来查看有关赌博结果的预先信息。虽然猴子将信息价值与主要奖励价值结合起来做出决定,但 OFC 神经元没有系统地整合这些变量的倾向,而是以正交方式对它们进行编码。这些结果表明,OFC 的主要作用是对与学习、注意力和决策相关的变量进行编码,而不是将它们整合到单一的价值尺度中。他们还建议,在评估完成之前,OFC 可能会被置于信息寻求决策层次结构的相对早期阶段。因此,我们的结果描绘了信息寻求决策的回路,并提出了好奇心的神经基础。
Decision-makers are curious and consequently value advance information about future events. We made use of this fact to test competing theories of value representation in Area 13 of orbitofrontal cortex (OFC). In a new task, we found that monkeys reliably sacrificed primary reward (water) to view advance information about gamble outcomes. While monkeys integrated information value with primary reward value to make their decisions, OFC neurons had no systematic tendency to integrate these variables, instead encoding them in orthogonal manners. These results suggest that the predominant role of the OFC is to encode variables relevant for learning, attention, and decision-making rather than integrating them into a single scale of value. They also suggest that OFC may be placed at a relatively early stage in the hierarchy of information-seeking decisions, before evaluation is complete. Thus, our results delineate a circuit for information-seeking decisions and suggest a neural basis for curiosity.
额叶中的神经元编码多个决策变量的值。
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