Neonatal stress modulates sickness behavior.
Neonatal stress modulates sickness behavior.
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DOI：
10.1016/j.bbi.2009.05.056
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发表时间：
2009-10
影响因子：
15.1
通讯作者：
Sheridan, John F.
中科院分区：
文献类型：
--
作者：
Avitsur, Ronit;Sheridan, John F.
早期环境的质量，特别是在新生儿时期，影响个体在成年后对压力和疾病的抵抗力的差异的发展。先前的一项研究表明，在流感病毒感染的成年小鼠中，新生应激增加了促炎细胞因子的表达和病毒复制。以下研究的目的是检验新生儿应激对免疫挑战的行为反应的终生影响。新生儿应激包括在发育的临界点将小鼠从母体中分离(母体分离，MSP)。在第一项研究中，从出生后第1天到第14天，每天将幼鼠从水坝中分离出来6小时。成年后，这些小鼠感染了A/PR8流感病毒。在第二项研究中，采用了类似的MSP范式，成年后给小鼠注射脂多糖(LPS)(IP)。在第三项研究中，幼鼠在出生后第4天或第9天从水坝中分离24小时。成年后，这些小鼠接受内毒素的ip注射。在所有三项研究中，都检查了免疫挑战后体重、食物和甜味剂摄入量的变化。如前所述，使用流感病毒感染或内毒素注射激活免疫系统会导致疾病行为，包括体重减轻、食欲不振和减少甜食溶液的消费。此外，新生儿应激诱导了更快的疾病行为动力学，并增加了这些症状的几个方面。结合以前的研究，这些发现表明，新生儿应激扰乱了对免疫挑战的先天抵抗力的调节，导致对免疫激活的免疫和行为反应增强。因此，早期压力事件的长期影响可能是个体健康差异和疾病易感性的基础。
The quality of the early environment, especially during the neonatal period, influences the development of individual differences in resistance to stress and illness in adulthood. A previous study demonstrated that neonatal stress augmented proinflammatory cytokine expression and viral replication in influenza virus-infected adult mice. The goal of the following study was to examine the lifelong effects of neonatal stress on the behavioral response to an immune challenge. Neonatal stress consisted of separating mouse pups from their dams (maternal separation, MSP) at critical points of their development. In the first study, pups were separated from the dam daily for 6 hr between postnatal day 1 and 14. As adults, these mice were infected with influenza A/PR8 virus. In a second study, a similar paradigm of MSP was employed, and as adults mice were injected with lipopolysaccharide (LPS) (ip). In a third study pups were separated from the dam for 24 hr on postnatal day 4 or 9. As adults, these mice received ip injections of LPS. In all three studies, changes in body weight, food and sweet solution consumption were examined following immune challenge. As previously described, activation of the immune system using influenza virus infection or LPS administration resulted in sickness behavior that consisted of body weight loss, anorexia and reduced consumption of a sweet solution. Furthermore, neonatal stress induced more rapid kinetics of sickness behavior and augmented several aspects of these symptoms. Together with previous studies, these findings suggest that neonatal stress disrupted the regulation of innate resistance to an immune challenge resulting in enhanced immunological and behavioral responses to immune activation. Thus, long lasting effects of early stress events may be the basis for individual differences in health and susceptibility to disease.
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影响因子：
4.4
作者：
Kruschinski, Carsten;Skripuletz, Thomas;von Hoersten, Stephan
通讯作者：
von Hoersten, Stephan
DOI：
10.1016/0169-328x(93)90189-v
发表时间：
1993-05-01
期刊：
MOLECULAR BRAIN RESEARCH
影响因子：
--
作者：
PLOTSKY, PM;MEANEY, MJ
通讯作者：
MEANEY, MJ
影响因子：
4.1
作者：
MEANEY, MJ;AITKEN, DH;SARRIEAU, A
通讯作者：
SARRIEAU, A
影响因子：
13.8
作者：
KENT, S;BLUTHE, RM;DANTZER, R
通讯作者：
DANTZER, R
影响因子：
15.1
作者：
Avitsur, Ronit;Hunzeker, John;Sheridan, John F.
通讯作者：
Sheridan, John F.