Brain-Derived Neurotrophic Factor, Depression, and Physical Activity: Making the Neuroplastic Connection.
Brain-Derived Neurotrophic Factor, Depression, and Physical Activity: Making the Neuroplastic Connection.
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DOI：
10.1155/2017/7260130
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发表时间：
2017
影响因子：
3.1
通讯作者：
Phillips C
中科院分区：
文献类型：
--
作者：
Phillips C
脑源性神经营养因子（BDNF）是一种神经营养因子，对参与情绪和认知功能的关键脑回路中神经元的存活、生长和维持至关重要。汇聚的证据表明，涉及BDNF的神经可塑性机制在重性抑郁症（MDD）和应激动物模型中发生了有害的改变。在此，临床和临床前证据表明，应激诱导的抑郁病理有助于改变MDD患者的BDNF水平和功能，从而在区域和回路水平上破坏神经可塑性。相反，减轻抑郁症相关症状的有效治疗剂（例如，抗抑郁药和体力活动）优化脑关键区域的BDNF，促进神经元健康和MDD相关回路的功能恢复，并增强药效反应。更好地了解BDNF、抑郁症、治疗作用机制和神经可塑性之间的相互关系是很重要的，因为它必然先于更有效的治疗方法的衍生和部署。
Brain-derived neurotrophic factor (BDNF) is a neurotrophin that is vital to the survival, growth, and maintenance of neurons in key brain circuits involved in emotional and cognitive function. Convergent evidence indicates that neuroplastic mechanisms involving BDNF are deleteriously altered in major depressive disorder (MDD) and animal models of stress. Herein, clinical and preclinical evidence provided that stress-induced depressive pathology contributes to altered BDNF level and function in persons with MDD and, thereby, disruptions in neuroplasticity at the regional and circuit level. Conversely, effective therapeutics that mitigate depressive-related symptoms (e.g., antidepressants and physical activity) optimize BDNF in key brain regions, promote neuronal health and recovery of function in MDD-related circuits, and enhance pharmacotherapeutic response. A greater knowledge of the interrelationship between BDNF, depression, therapeutic mechanisms of action, and neuroplasticity is important as it necessarily precedes the derivation and deployment of more efficacious treatments.
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