Mechanisms controlling germline cyst breakdown and primordial follicle formation
Mechanisms controlling germline cyst breakdown and primordial follicle formation
复制标题
控制种系囊肿破裂和原始卵泡形成的机制
DOI:
10.1007/s00018-017-2480-6
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发表时间:
2017-02
影响因子:
8
通讯作者:
Xia Guoliang
中科院分区:
文献类型:
--
作者:
Wang Chao;Zhou Bo;Xia Guoliang
In fetal females, oogonia proliferate immediately after sex determination. The progress of mitosis in oogonia proceeds so rapidly that the incompletely divided cytoplasm of the sister cells forms cysts. The oogonia will then initiate meiosis and arrest at the diplotene stage of meiosis I, becoming oocytes. Within each germline cyst, oocytes with Balbiani bodies will survive after cyst breakdown (CBD). After CBD, each oocyte is enclosed by pre-granulosa cells to form a primordial follicle (PF). Notably, the PF pool formed perinatally will be the sole lifelong oocyte source of a female. Thus, elucidating the mechanisms of CBD and PF formation is not only meaningful for solving mysteries related to ovarian development but also contributes to the preservation of reproduction. However, the mechanisms that regulate these phenomena are largely unknown. This review summarizes the progress of cellular and molecular research on these processes in mice and humans.
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影响因子:
9.2
作者:
Llense, Flora;Martin-Blanco, Enrique
通讯作者:
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DOI:
10.2741/e579
发表时间:
2012-06
期刊:
Frontiers in bioscience
影响因子:
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DOI:
10.1007/978-1-4614-8214-7
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2013
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--
影响因子:
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通讯作者:
Irun R. Cohen;John D Lambris;S. S. Kim-S.;R. Gosden;Meltem Kurus;Cengiz Karakaya;Mete Hakan Karalok
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S. Soyal;A. Amleh;J. Dean