Cytokine levels in synovial fluid from hips with well-functioning or loose prostheses.
Cytokine levels in synovial fluid from hips with well-functioning or loose prostheses.
复制标题
功能良好或假体松动的髋关节滑液中的细胞因子水平。
DOI：
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发表时间：
1999
影响因子：
--
通讯作者：
J. Kärrholm
中科院分区：
文献类型：
--
作者：
B. Nivbrant;K. Karlsson;J. Kärrholm
我们分析了88个髋关节的滑液，其中38个髋关节有骨关节炎，12个髋关节功能良好，38个髋关节假体松动。使用ELISA技术测量TNF-α、IL-1 β（71髋）和IL-6（45髋）的水平。与骨关节炎患者相比，功能良好或假体松动的关节TNF-α水平显著升高。髋关节无菌性松动也有较高的IL-1 β水平，但没有IL-6相比，没有植入物。TNF-α和IL-1 β的水平在假体稳定和松动的髋关节之间没有差异。与I型松动的髋关节相比，II型和III型骨吸收（Gustilo-Pasternak）的髋关节TNF-α水平更高。关节液中的细胞因子水平不受植入物原位时间或年龄、性别或传统X线片上测量的骨质溶解区域的影响。我们的研究结果支持了这样的理论，即关节囊中的巨噬细胞在早期阶段增加了TNF-α的产生，这可能是因为颗粒负荷和没有临床松动。由于TNF-α在溶骨性过程中具有重要作用，因此应保护界面免受关节液的渗透。
We analysed synovial fluid from 88 hips, 38 with osteoarthritis and 12 with well-functioning and 38 with loose hip prostheses. The levels of TNF-alpha, IL-1beta (71 hips) and IL-6 (45 hips) were measured using the ELISA technique. Joints with well-functioning or loose prostheses had significantly increased levels of TNF-alpha compared with those with osteoarthritis. Hips with aseptic loosening also had higher levels of IL-1beta but not of IL-6 compared with those without an implant. The levels of TNF-alpha and IL-1beta did not differ between hips with stable and loose prostheses. Higher levels of TNF-alpha were found in hips with bone resorption of type II and type III (Gustilo-Pasternak) compared with those with type-I loosening. The level of cytokines in joint fluid was not influenced by the time in situ of the implants or the age, gender or area of the osteolysis as measured on conventional radiographs. Our findings support the theory that macrophages in the joint capsule increase the production of TNF-alpha at an early phase probably because of particle load and in the absence of clinical loosening. Since TNF-alpha has an important role in the osteolytic process, the interfaces should be protected from penetration of joint fluid.
影响因子：
3.5
作者：
SHANBHAG, AS;JACOBS, JJ;GLANT, TT
通讯作者：
GLANT, TT
DOI：
10.1002/jbm.820280111
发表时间：
1994-01-01
期刊：
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH
影响因子：
--
作者：
SHANBHAG, AS;JACOBS, JJ;GLANT, TT
通讯作者：
GLANT, TT