Nasal Tumor Vaccination Protects against Lung Tumor Development by Induction of Resident Effector and Memory Anti-Tumor Immune Responses.
Nasal Tumor Vaccination Protects against Lung Tumor Development by Induction of Resident Effector and Memory Anti-Tumor Immune Responses.
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DOI：
10.3390/pharmaceutics15020445
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发表时间：
2023-01-29
期刊：
影响因子：
5.4
通讯作者：
Jones HP
中科院分区：
文献类型：
--
作者：
Donkor M;Choe J;Reid DM;Quinn B;Pulse M;Ranjan A;Chaudhary P;Jones HP
肺转移是癌症相关死亡的主要原因。在这里，我们表明，我们的工程CpG包被的肿瘤抗原（标签）封装的纳米粒子（NP）的鼻内递送-鼻纳米疫苗-显着减少肺外肿瘤的静脉内挑战的肺定植。对肿瘤细胞肺定植的保护与诱导局部粘膜相关效应和驻留记忆T细胞以及增加细支气管肺泡灌洗液伊加和血清IgG抗体应答有关。鼻纳米疫苗诱导的T细胞介导的抗肿瘤粘膜免疫应答显示增加了肺源性CD 8 + T细胞的IFN-γ和颗粒酶B的肿瘤特异性产生。这些发现表明，我们的工程鼻纳米疫苗有可能在肺部接种肿瘤之前用作预防方法，从而防止现有肺外肿瘤的明显肺转移。
Lung metastasis is a leading cause of cancer-related deaths. Here, we show that intranasal delivery of our engineered CpG-coated tumor antigen (Tag)-encapsulated nanoparticles (NPs)—nasal nano-vaccine—significantly reduced lung colonization by intravenous challenge of an extra-pulmonary tumor. Protection against tumor-cell lung colonization was linked to the induction of localized mucosal-associated effector and resident memory T cells as well as increased bronchiolar alveolar lavage-fluid IgA and serum IgG antibody responses. The nasal nano-vaccine-induced T-cell-mediated antitumor mucosal immune response was shown to increase tumor-specific production of IFN-γ and granzyme B by lung-derived CD8+ T cells. These findings demonstrate that our engineered nasal nano-vaccine has the potential to be used as a prophylactic approach prior to the seeding of tumors in the lungs, and thereby prevent overt lung metastases from existing extra pulmonary tumors.
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影响因子：
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