Effect of inactivation and disinhibition of the oculomotor vermis on saccade adaptation.
Effect of inactivation and disinhibition of the oculomotor vermis on saccade adaptation.
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DOI：
10.1016/j.brainres.2011.05.027
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发表时间：
2011-07-15
期刊：
影响因子：
2.9
通讯作者：
Fuchs AF
中科院分区：
文献类型：
--
作者：
Kojima Y;Soetedjo R;Fuchs AF
小脑具有适应各种运动行为以补偿持续的自然或人为引起的运动准确性误差的能力。为了适应称为扫视的注视方向的快速变化，小脑的动眼蚓部 (OMV) 必须完好无损。我们通过操纵γ氨基丁酸（GABA）（蚓部许多神经元使用的递质）来破坏 OMV 的神经回路。我们注射蝇蕈醇（一种 GABA 激动剂）来灭活 OMV，或注射荷包牡丹碱（一种拮抗剂）来阻断 GABA 抑制。我们之前的研究表明，注射蝇蕈醇会导致同向扫视达不到目标，而荷包牡丹碱注射则会导致大多数同向扫视超出目标。一旦这些视力障碍稳定下来，我们就测试了猴子使扫视大小适应扫视内目标步骤的能力，这些目标步骤产生一致的扫视下冲（需要幅度增加适应）或过冲（需要幅度减少适应）。注射蝇蕈醇消除了运动性扫视的振幅增加适应，但对振幅减少适应没有影响，或偶尔促进。相反，注射荷包牡丹碱会损害振幅降低适应，并且通常会促进振幅增加适应。这两种药物都没有对反向眼跳的适应产生一致的效果。总而言之，这些数据表明 OMV 活性对于振幅增加适应是必要的，而振幅减少适应可能涉及 OMV 内的抑制电路。
The ability to adapt a variety of motor acts to compensate for persistent natural or artificially induced errors in movement accuracy requires the cerebellum. For adaptation of the rapid shifts in the direction of gaze called saccades, the oculomotor vermis (OMV) of the cerebellum must be intact. We disrupted the neural circuitry of the OMV by manipulating gamma aminobutyric acid (GABA), the transmitter used by many neurons in the vermis. We injected either muscimol, an agonist of GABA, to inactivate the OMV or bicuculline, an antagonist, to block GABA inhibition. Our previous study showed that muscimol injections cause ipsiversive saccades to fall short of their targets, whereas bicuculline injections cause most ipsiversive saccades to overshoot. Once these dysmetrias had stabilized, we tested the monkey’s ability to adapt saccade size to intra-saccadic target steps that produced a consistent saccade under-shoot (amplitude increase adaptation required) or overshoot (amplitude decrease adaptation required). Injections of muscimol abolished the amplitude increase adaptation of ipsiversive saccades, but had either no effect, or occasionally facilitated, amplitude decrease adaptation. In contrast, injections of bicuculline impaired amplitude decrease adaptation and usually facilitated amplitude increase adaptation. Neither drug produced consistent effects on the adaptation of contraversive saccades. Taken together, these data suggest that OMV activity is necessary for amplitude increase adaptation, whereas amplitude decrease adaptation may involve the inhibitory circuits within the OMV.
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影响因子：
5.3
作者：
Barash, S;Melikyan, A;Thier, P
通讯作者：
Thier, P
影响因子：
2.5
作者：
Tonkovic-Capin, V;Stucke, AG;Zuperku, EJ
通讯作者：
Zuperku, EJ
DOI：
10.1523/jneurosci.3111-10.2010
发表时间：
2010-10-20
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Quessy S;Quinet J;Freedman EG
通讯作者：
Freedman EG
DOI：
10.1111/j.1749-6632.2002.tb02816.x
发表时间：
2002-01-01
期刊：
NEUROBIOLOGY OF EYE MOVEMENTS: FROM MOLECULES TO BEHAVIOR
影响因子：
--
作者：
Robinson, FR;Fuchs, AF;Noto, CT
通讯作者：
Noto, CT
影响因子：
2.5
作者：
Takagi, M;Zee, DS;Tamargo, RJ
通讯作者：
Tamargo, RJ