Patient-Specific Minimum-Dose Imaging Protocols for Statistical Image Reconstruction in C-arm Cone-Beam CT Using Correlated Noise Injection.
Patient-Specific Minimum-Dose Imaging Protocols for Statistical Image Reconstruction in C-arm Cone-Beam CT Using Correlated Noise Injection.
复制标题
使用相关噪声注入在 C 形臂锥束 CT 中进行统计图像重建的患者特定最小剂量成像协议。
DOI：
10.1117/12.2043083
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Siewerdsen,JH
中科院分区：
文献类型：
--
作者：
Wang,AS;Stayman,JW;Otake,Y;Khanna,AJ;Gallia,GL;Siewerdsen,JH
目的提出并验证一种准确描述C臂锥束CT（CBCT）中低剂量成像技术影响的新方法，允许在需要重复术中扫描的情况下，在患者特定的基础上识别适合于给定成像任务的最小剂量协议。通过比较X射线量子噪声和探测器电子噪声和相关性（探测器模糊），将适当幅度和相关性的噪声注入到来自在手术开始时采集的初始CBCT的投影中。然后重建产生的噪声投影，以产生低剂量预览（LDP）图像，该图像在滤波反投影和统计图像重建中准确描述了任何剂量水平下的图像质量。验证研究进行了一个移动的C形臂，与噪声注入方法应用于图像的拟人化的头部幻影和尸体躯干在一系列的低剂量technology.ResultsComparison预览和真实的CBCT图像在全方位的技术表现出准确的噪声幅度（~5%）和相关性（匹配噪声功率谱，SNR）。其他图像质量特性（例如，空间分辨率，对比度，和伪影与射束硬化和散射）也逼真地呈现在所有水平的剂量和跨重建方法，包括统计reconstruction.ConclusionGenerating低剂量预览图像的协议范围广泛，提供了一个有用的方法来选择最小剂量的技术，占成像任务，病人的具体解剖结构的复杂因素，观察者的喜好。在统计重建中准确模拟低剂量采集的影响的能力提供了一种特别有价值的方式来识别低剂量限制，该方式不依赖于非线性重建过程的模型或观测器性能的模型。
PurposeA new method for accurately portraying the impact of low-dose imaging techniques in C-arm cone-beam CT (CBCT) is presented and validated, allowing identification of minimum-dose protocols suitable to a given imaging task on a patient-specific basis in scenarios that require repeat intraoperative scans.MethodTo accurately simulate lower-dose techniques and account for object-dependent noise levels (x-ray quantum noise and detector electronics noise) and correlations (detector blur), noise of the proper magnitude and correlation was injected into the projections from an initial CBCT acquired at the beginning of a procedure. The resulting noisy projections were then reconstructed to yield low-dose preview (LDP) images that accurately depict the image quality at any level of reduced dose in both filtered backprojection and statistical image reconstruction. Validation studies were conducted on a mobile C-arm, with the noise injection method applied to images of an anthropomorphic head phantom and cadaveric torso across a range of lower-dose techniques.ResultsComparison of preview and real CBCT images across a full range of techniques demonstrated accurate noise magnitude (within ~5%) and correlation (matching noise-power spectrum, NPS). Other image quality characteristics (e.g., spatial resolution, contrast, and artifacts associated with beam hardening and scatter) were also realistically presented at all levels of dose and across reconstruction methods, including statistical reconstruction.ConclusionGenerating low-dose preview images for a broad range of protocols gives a useful method to select minimum-dose techniques that accounts for complex factors of imaging task, patient-specific anatomy, and observer preference. The ability to accurately simulate the influence of low-dose acquisition in statistical reconstruction provides an especially valuable means of identifying low-dose limits in a manner that does not rely on a model for the nonlinear reconstruction process or a model of observer performance.
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