Extension of the intravoxel incoherent motion model to non-gaussian diffusion in head and neck cancer.
Extension of the intravoxel incoherent motion model to non-gaussian diffusion in head and neck cancer.
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DOI：
10.1002/jmri.23770
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发表时间：
2012-11
影响因子：
4.4
通讯作者：
Shukla-Dave, Amita
中科院分区：
文献类型：
--
作者：
Lu, Yonggang;Jansen, Jacobus F. A.;Mazaheri, Yousef;Stambuk, Hilda E.;Koutcher, Jason A.;Shukla-Dave, Amita
To extend the intravoxel incoherent motion (IVIM) magnetic resonance imaging (MRI) model to restricted diffusion and to simultaneously quantify the perfusion and restricted diffusion parameters in neck nodal metastases. The non-Gaussian (NG)-IVIM model was developed and tested on diffusion-weighted MRI data collected on a 1.5-Tesla MRI scanner from 8 patients with head and neck cancer. Voxel-wise parameter quantification was performed by using a noise-rectified least-square fitting method. The NG-IVIM, IVIM, Kurtosis, and ADC (apparent diffusion coefficient) models were used for comparison. For each voxel, within the metastatic node, the optimal model was determined using the Bayesian Information Criterion. The voxel percentage preferred by each model was calculated and the optimal model map was generated. Monte Carlo simulations were performed to evaluate the accuracy and precision dependency of the new model. For the 8 neck nodes, the range of voxel percentage preferred by the NG-IVIM model was 2.3% - 79.3%. The optimal modal maps showed heterogeneities within the tumors. The Monte Carlo simulations demonstrated that the accuracy and precision of the NG-IVIM model improved by increasing signal-to-noise ratio and b value. The NG-IVIM model characterizes perfusion and restricted diffusion simultaneously in neck nodal metastases.
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影响因子：
2.9
作者：
Jensen, Jens H.;Helpern, Joseph A.
通讯作者：
Helpern, Joseph A.
影响因子：
3.8
作者：
MCGIBNEY, G;SMITH, MR
通讯作者：
SMITH, MR
影响因子：
19.7
作者：
Luciani, Alain;Vignaud, Alexandre;Rahmouni, Alain
通讯作者：
Rahmouni, Alain
影响因子：
4.4
作者：
Qi, Jing;Olsen, Nancy J.;Park, Jane H.
通讯作者：
Park, Jane H.
影响因子：
4.4
作者：
Falangola, Maria F.;Jensen, Jens H.;Babb, James S.;Hu, Caixia;Castellanos, Francisco X.;Di Martino, Adriana;Ferris, Steven H.;Helpern, Joseph A.
通讯作者：
Helpern, Joseph A.