Age-related non-Gaussian diffusion patterns in the prefrontal brain.
Age-related non-Gaussian diffusion patterns in the prefrontal brain.
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DOI：
10.1002/jmri.21604
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发表时间：
2008-12
影响因子：
4.4
通讯作者：
Helpern, Joseph A.
中科院分区：
文献类型：
--
作者：
Falangola, Maria F.;Jensen, Jens H.;Babb, James S.;Hu, Caixia;Castellanos, Francisco X.;Di Martino, Adriana;Ferris, Steven H.;Helpern, Joseph A.
使用一种称为扩散峰度成像（DKI）的新方法研究水扩散的非高斯行为，以表征前额叶大脑皮层微结构的年龄相关MR扩散模式。测量平均扩散率（MD），各向异性分数（FA）和平均峰度（MK）进行了比较，在24名健康志愿者（青少年，年轻人，老年人），年龄从13岁到85岁。使用Mann-Whitney检验比较受试者组的扩散测量值，并使用线性回归表征每个扩散测量值随年龄的变化。我们发现，老年组的MD增加，FA减少，与年龄相关的变化显着。目前的研究表明，不同年龄范围的平均峰度模式不同，平均峰度（MK）和MK峰位置与年龄相关的显着相关性，表明扩散峰度能够表征和测量与年龄相关的扩散变化的灰色和白色物质，在发育和老化的大脑。
To characterize age-related MR diffusion patterns of the prefrontal brain cortex microstructure using a new method for investigating the non-Gaussian behavior of water diffusion called diffusional kurtosis imaging (DKI). Measures of mean diffusivity (MD), fractional anisotropy (FA) and mean kurtosis (MK) were compared in the prefrontal brain cortex of 24 healthy volunteers (adolescents, young adults, and elderly) ranging from age 13 to 85 years. A Mann-Whitney test was used to compare subject groups with respect to the diffusion measures, and linear regression was used to characterize the change in each diffusion measure as a function of age. We found significant age-related changes in the elderly adult group, with increase of MD and decrease of FA. The current study demonstrates distinct mean kurtosis patterns for different age-ranges, with significant age-related correlation for mean kurtosis (MK) and MK peak position, showing that diffusional kurtosis is able to characterize and measure age-related diffusion changes for both grey and white matter, in the developing and aging brain.
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影响因子：
9.9
作者：
Guttmann, CRG;Jolesz, FA;Albert, MS
通讯作者：
Albert, MS
影响因子：
3.3
作者：
Reese, TG;Heid, O;Wedeen, VJ
通讯作者：
Wedeen, VJ
影响因子：
3.3
作者：
Jensen, JH;Helpern, JA;Kaczynski, K
通讯作者：
Kaczynski, K
影响因子：
5.7
作者：
Good, CD;Johnsrude, IS;Frackowiak, RSJ
通讯作者：
Frackowiak, RSJ
DOI：
10.1111/j.1365-2990.1980.tb00283.x
发表时间：
1980-01-01
影响因子：
5
作者：
MILLER, AKH;ALSTON, RL;CORSELLIS, JAN
通讯作者：
CORSELLIS, JAN