Cocaine impairs follicular phase pulsatile gonadotropin secretion in rhesus monkeys.
Cocaine impairs follicular phase pulsatile gonadotropin secretion in rhesus monkeys.
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可卡因损害恒河猴的卵泡期脉动促性腺激素分泌。
DOI：
10.1016/s1071-5576(98)00034-3
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发表时间：
1998
期刊：
影响因子：
--
通讯作者：
Schenken,RS
中科院分区：
文献类型：
--
作者：
Chen,EC;Samuels,MH;Luther,MF;King,TS;Eddy,CA;Siler-Khodr,TM;Schenken,RS
ObjectiveTo assess cocaine’s effect on follicular phase pulsatile gonadotropin secretion in normally cycling rhesus monkeys.MethodsSixteen monkeys were paired by body weight and randomized to receive intravenous saline (n = 8) or cocaine (4 mg/kg, n = 8) daily on cycle days 2 to 14. Monkeys were chronically cannulated to allow frequent blood collections without anesthesia. Blood samples were obtained every 15 minutes for 8 hours in early (EFP; cycle days 1 to 5); mid- (MFP; cycle days 6 to 10), and late (LFP; cycle days 11 to 15) follicular phase. Plasma concentrations of LH, FSH, and estradiol-17β (E2) were determined by radioimmunoassay. Pulses were identified by cluster analysis. Statistical differences were determined by analysis of variance (ANOVA) and Sidak’s multiple comparison test.ResultsSeven out of eight monkeys in the control group demonstrated timely ovulation. Only one monkey in the cocaine-treated group ovulated. Similar gonadotropin pulse intervals (7 to 90 minutes) were observed throughout the follicular phase in both the controls and cocaine-treated monkeys. LH and FSH pulse amplitudes increased significantly from the EFP/MFP to the LFP in controls. In cocaine-treated monkeys, gonadotropin pulse amplitudes remained at EFP/MFP levels throughout the study period. The mean gonadotropin pulse amplitude and the mean E2levels in the LFP were significantly greater in controls as compared with cocaine-treated monkeys (P < .001).ConclusionThese findings demonstrate that cocaine suppresses the normal increase in LH and FSH pulse amplitude seen in the LFP. Further studies are in progress to determine the mechanism of cocaine’s disruption of the hypothalamic-pituitary-ovarian axis.
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可卡因对大鼠动情周期的慢性破坏：剂量依赖性效应。
DOI：
--
发表时间：
1993
期刊：
The Journal of pharmacology and experimental therapeutics
影响因子：
--
作者：
King,TS;Canez,MS;Gaskill,S;Javors,MA;Schenken,RS
通讯作者：
Schenken,RS
可卡因和性功能障碍：古柯妈妈的诅咒。
影响因子：
2.8
作者：
R. K. Siegel
通讯作者：
R. K. Siegel
高雄激素女性中雄激素和胰岛素对口服葡萄糖挑战的反应。
影响因子：
6.7
作者：
S. Smith;V. Ravnikar;R. Barbieri
通讯作者：
R. Barbieri
影响因子：
3.2
作者：
BACKSTROM, CT;MCNEILLY, AS;BAIRD, DT
通讯作者：
BAIRD, DT
卵泡期可卡因给药对恒河猴月经和卵巢周期的影响。
影响因子：
9.8
作者：
Potter,DA;Moreno,A;Luther,MF;Eddy,CA;Siler-Khodr,TM;King,TS;Schenken,RS
通讯作者：
Schenken,RS