New hope for preventing preterm birth: The promise of vaginal nanoformulations
New hope for preventing preterm birth: The promise of vaginal nanoformulations
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预防早产的新希望：阴道纳米制剂的前景
DOI：
10.54844/prm.2022.0100
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
S. Reznik
中科院分区：
文献类型：
--
作者：
S. Reznik
早产 (PTB) 定义为妊娠 37 周之前出生，占围产期发病率和死亡率的绝大多数。 [1-3] 可悲的是，世界卫生组织收集的数据表明，过去几十年来，全球PTB的年发病率并没有改善，大多数国家都超过10%。 [4] 发展中国家的 PTB 率普遍较高；在工业化国家中，美国 (US) 的 PTB 发生率最高。 [2] 特别是在美国，新生儿学的进步比产科领域的进步更快，因此越来越多的出生时越来越接近生存能力的新生儿在新生儿重症监护病房中存活下来，但却面临着一系列的医疗挑战。 PTB 的急性后遗症，如呼吸窘迫综合征和坏死性小肠结肠炎，被终生呼吸、代谢和神经系统异常所取代，包括早产儿视网膜病变和脑瘫。 [5] PTB 的个人和社会成本是巨大的。
Defined as birth before 37 completed weeks of gestation, preterm birth (PTB) accounts for the vast majority of perinatal morbidity and mortality. [1–3] Sadly, data collected by the World Health Organization indicate that the annual rate of PTB worldwide has not improved over the last several decades and is greater than 10% in most countries. [4] PTB rates are generally higher in the developing world; among industrialized nations, the United States (US) has the highest rate of PTB. [2] In the US particularly, advances in neonatology have occurred more rapidly than in the field of obstetrics, so that more and more neonates born closer and closer to the cusp of viability survive their neonatal intensive care unit stay, only to live with a constellation of medical challenges. The acute sequelae of PTB, such as respiratory distress syndrome and necrotizing enterocolitis, are replaced by lifelong respiratory, metabolic and neurologic abnormalities, including retinopathy of prematurity and cerebral palsy. [5] The personal and societal costs of PTB are enormous.
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影响因子：
6
作者：
Vyas, Vibhuti;Ashby, Charles R., Jr.;Reznik, Sandra E.
通讯作者：
Reznik, Sandra E.
影响因子：
16.1
作者：
Lai, Samuel K.;Wang, Ying-Ying;Hanes, Justin
通讯作者：
Hanes, Justin
DOI：
10.1016/j.ajpath.2013.05.006
发表时间：
2013-08
期刊：
The American journal of pathology
影响因子：
--
作者：
Sruthi Sundaram;C. Ashby;Ryan Pekson;Vaishali Sampat;R. Sitapara;L. Mantell;Chih-Hung Chen;H. Yen;K. Abhichandani;S. Munnangi;Nikhil Khadtare;R. Stephani;S. Reznik
通讯作者：
Sruthi Sundaram;C. Ashby;Ryan Pekson;Vaishali Sampat;R. Sitapara;L. Mantell;Chih-Hung Chen;H. Yen;K. Abhichandani;S. Munnangi;Nikhil Khadtare;R. Stephani;S. Reznik
影响因子：
10.8
作者：
Nel AE MD/DSc
通讯作者：
Nel AE MD/DSc