Mucus-penetrating nanoparticles for drug and gene delivery to mucosal tissues.
Mucus-penetrating nanoparticles for drug and gene delivery to mucosal tissues.
复制标题
DOI：
10.1016/j.addr.2008.11.002
复制
发表时间：
2009-02-27
影响因子：
16.1
通讯作者：
Hanes, Justin
中科院分区：
文献类型：
--
作者：
Lai, Samuel K.;Wang, Ying-Ying;Hanes, Justin
粘液是一种粘弹性和粘性凝胶，可保护肺气道、胃肠道（GI）、阴道、眼睛和其他粘膜表面。大多数外来颗粒，包括常规的基于颗粒的药物递送系统，通过空间阻碍和/或粘附被有效地捕获在人粘液层中。取决于解剖位置，捕获的颗粒通常在数秒至数小时内从粘膜组织中去除，从而强烈限制了局部持续药物递送的持续时间。如果药物和基因能够以可控的方式更有效地传递到底层粘膜组织，许多使人衰弱的疾病可以得到更有效的治疗，副作用也更少。这篇综述首先描述了顽强的粘液屏障性能，排除了治疗颗粒的有效渗透。然后，它回顾了新的粘液穿透颗粒的设计和开发，可以避免快速粘液清除机制，从而提供针对性或持续的药物输送局部治疗粘膜组织。
Mucus is a viscoelastic and adhesive gel that protects the lung airways, gastrointestinal (GI) tract, vagina, eye and other mucosal surfaces. Most foreign particulates, including conventional particle-based drug delivery systems, are efficiently trapped in human mucus layers by steric obstruction and/or adhesion. Trapped particles are typically removed from the mucosal tissue within seconds to a few hours depending on anatomical location, thereby strongly limiting the duration of sustained drug delivery locally. A number of debilitating diseases could be treated more effectively and with fewer side effects if drugs and genes could be more efficiently delivered to the underlying mucosal tissues in a controlled manner. This review first describes the tenacious mucus barrier properties that have precluded the efficient penetration of therapeutic particles. It then reviews the design and development of new mucus-penetrating particles that may avoid rapid mucus clearance mechanisms, and thereby provide targeted or sustained drug delivery for localized therapies in mucosal tissues.
登录
查看更多内容
影响因子：
24.3
作者：
App, EM;Baran, D;King, M
通讯作者：
King, M
影响因子：
10.8
作者：
Bures, P;Huang, YB;Peppas, NA
通讯作者：
Peppas, NA
影响因子：
4.1
作者：
CARLSTEDT, I;LINDGREN, H;WINGERUP, L
通讯作者：
WINGERUP, L
DOI：
10.1152/ajpgi.2001.280.5.g922
发表时间：
2001-05-01
影响因子：
4.5
作者：
Atuma, C;Strugala, V;Holm, L
通讯作者：
Holm, L
影响因子：
6.1
作者：
Boskey, ER;Cone, RA;Moench, TR
通讯作者：
Moench, TR