Mineralogical signatures of stone formation mechanisms.
Mineralogical signatures of stone formation mechanisms.
复制标题
石材形成机制的矿物学特征。
DOI：
10.1007/s00240-010-0288-z
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发表时间：
2010-08
影响因子：
--
通讯作者：
Khan SR
中科院分区：
文献类型：
--
作者：
Gower LB;Amos FF;Khan SR
生物矿化涉及的机制是通过与有机基质的相互作用来调节的。就结石形成而言，有机大分子在复杂的泌尿环境中的作用尚不清楚，但矿物学“特征”的存在表明，结石形成的某些方面可能是由酸性蛋白质诱导的非经典结晶过程造成的。在许多生物控制的矿化反应中都检测到了无定形前体，该反应被认为是通过可溶性酸性蛋白和矿物离子之间的非特异性相互作用来调节的。使用体外模型系统，我们发现由酸性多肽诱导的液相无定形矿物前体可以产生类似于兰德尔斑块和肾结石中发现的晶体结构。这种聚合物诱导的液体前体 (PILP) 过程会形成聚结矿物球团、具有同心层状结构的致密球晶、矿物涂层和“水泥”以及与胶原相关的矿化。通过使用体外模型系统，可以解决这些晶体学特征形成所涉及的机制，从而增强我们对蛋白质在结石形成中发挥的潜在作用的理解。
The mechanisms involved in biomineralization are modulated through interactions with organic matrix. In the case of stone formation, the role of the organic macromolecules in the complex urinary environment is not clear, but the presence of mineralogical ‘signatures’ suggests that some aspects of stone formation may result from a non-classical crystallization process that is induced by acidic proteins. An amorphous precursor has been detected in many biologically-controlled mineralization reactions, which is thought to be regulated by non-specific interactions between soluble acidic proteins and mineral ions. Using in vitro model systems, we find that a liquid-phase amorphous mineral precursor induced by acidic polypeptides can lead to crystal textures that resemble those found in Randall’s plaque and kidney stones. This polymer-induced liquid-precursor (PILP) process leads to agglomerates of coalesced mineral spherules, dense-packed spherulites with concentric laminations, mineral coatings and ‘cements’, and collagen-associated mineralization. Through the use of in vitro model systems, the mechanisms involved in the formation of these crystallographic features may be resolved, enhancing our understanding of the potential role(s) that proteins play in stone formation.
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影响因子：
3
作者：
Beniash, Elia;Metzler, Rebecca A.;Lam, Raymond S. K.;Gilbert, P. U. P. A.
通讯作者：
Gilbert, P. U. P. A.
DOI：
10.1098/rspb.1997.0066
发表时间：
1997-03-22
影响因子：
4.7
作者：
Beniash, E;Aizenberg, J;Weiner, S
通讯作者：
Weiner, S
影响因子：
3
作者：
Evan, Andrew P.
通讯作者：
Evan, Andrew P.
影响因子：
62.1
作者：
Gower, Laurie B.
通讯作者：
Gower, Laurie B.
影响因子：
3.9
作者：
Amos, Fairland F.;Sharbaugh, Denise M.;Volkmer, Dirk
通讯作者：
Volkmer, Dirk