Biomimetic model systems for investigating the amorphous precursor pathway and its role in biomineralization.
Biomimetic model systems for investigating the amorphous precursor pathway and its role in biomineralization.
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DOI：
10.1021/cr800443h
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发表时间：
2008-11
期刊：
影响因子：
62.1
通讯作者：
Gower, Laurie B.
中科院分区：
文献类型：
--
作者：
Gower, Laurie B.
生物形成的硬组织，被称为生物矿物，多年来一直引起材料工程界的兴趣，因为在生物无机晶体的沉淀过程中施加了高度的晶体学控制。近年来，人们的注意力发生了转移，从以前的研究集中在通过常规结晶途径调节晶体形态的特定有机-无机相互作用，到最近的研究发现许多生物矿物是通过无定形前体途径形成的。很明显，我们以前认为我们已经了解了生物矿物的东西可能与真正理解生物矿化的机制有关，也可能无关。在亲眼目睹了这种范式转变之后，我倾向于从这个历史的角度进行回顾，我希望在这里能够对我们在哪里，我们在哪里以及我们将走向何方的一些想法进行保留，以了解这些贝壳和其他生物矿物是如何形成的。因此，本综述的一个目标是尝试提供先前文献和新文献之间的联系，这可能对该领域的新人有用，我怀疑他们可能会发现在这段时间内将这些不同类型的研究结果整合在一起是令人困惑和困难的。第二个目标是尝试和整合从体外模型系统中获得的一些知识，这可能更适合于获得机械信息，在体内和体外生物矿物的观察研究。第三个目标是证明在生物矿物系统中可能存在某些统一的原则，这些生物矿物系统似乎非常多样化，例如硅藻，软体动物壳，脊椎动物的骨骼和牙齿。最终目标（不那么隐藏的议程）是证明不仅有很大的可能性，许多生物矿物是由无定形前体形成的，而且无定形相可能具有赋予系统新的处理能力的流体特性。当然，那些了解我的工作的人会很容易地认为我指的是聚合物诱导的液体前体（PILP）过程，这是我实验室的主要重点。沿着这些路线，提出了一些新的假设，关于某些生物矿物的形态发生，如软体动物珍珠层，肾结石，骨骼和牙齿，沿着的文献综述，为这些新的想法提供支持。其目的是在这一迅速兴起的领域激发深思熟虑的讨论，这似乎提供了一个统一的原则，在生物矿化。
Biologically formed hard tissues, referred to as biominerals, have intrigued the materials engineering community for years because of the high degree of crystallographic control that is exerted during the precipitation of the bioinorganic crystals. In recent years, there has been a shift in attention, from prior studies that focused on specific organic-inorganic interactions that modulate the crystal morphology via the conventional crystallization pathway, to recent studies that find that many biominerals are formed via an amorphous precursor pathway. It has become clear that the things we thought we had learned about biominerals before may or may not be relevant to truly understanding the mechanisms involved in biomineralization. Having witnessed this paradigm shift first hand, I am inclined to provide a review from this historical perspective, where I hope to belay some ideas about where we were, where we are, and where we are going, with respect to understanding how these shells and other biominerals are formed. Therefore, one goal of this review is to try and provide a link between the prior literature and the new literature, which might be useful to newcomers in the field, whom I suspect may find it confusing and difficult to integrate the findings in these different types of studies across this time period. A second goal is to try and integrate some of the knowledge obtained from in Vitro model systems, which can be more amenable to obtaining mechanistic information, with the in ViVo and ex ViVo observational studies on biominerals. A third goal is to demonstrate that there may be certain unifying principles found in biomineral systems that seem widely diverse, such as diatoms, mollusk shells, and vertebrate bones and teeth. A final goal (the not so hidden agenda), is to demonstrate not only that there is as strong a likelihood that many biominerals are formed by an amorphous precursor but also that the amorphous phase may possess fluidic properties that impart new processing capabilities to the system. Of course, those who know my work will readily assess that I am referring to the polymer-induced liquid-precursor (PILP) process, which has been a primary focus in my laboratory. Along these lines, some new hypotheses are presented regarding the morphogenesis of certain biominerals, such as mollusk nacre, kidney stones, and bones and teeth, along with a review of the literature that provides support to these new ideas. The intent is to stimulate thoughtful discussions in this rapidly emerging area, which seemingly provides a unifying principle in biomineralization.
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影响因子：
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DOI：
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影响因子：
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通讯作者：
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